Controlled drug delivery technology has progressed over the last six decades. This
progression began in 1952 with the introduction of the first sustained release formulation …

Gene therapy is a promising new technique for treating many serious incurable diseases,
such as cancer and genetic disorders. The main problem limiting the application of this …

Nanomaterials based on chitosan have emerged as promising carriers of therapeutic agents
for drug delivery due to good biocompatibility, biodegradability, and low toxicity. Chitosan …

Nanoparticle surface charge density plays an important role in many applications, such as
drug delivery and cellular uptake. In this study, surface charge properties of silica …

This study aims at developing chitosan-based nanoparticles suitable for an intravenous
administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing …

Since there are different kinds of chitosan, obtained from different sources of chitin and
routes, it is very important to study which are the best conditions in order to obtain …

Chitosan-based nano/microencapsulation is under increasing investigation for the delivery
of drugs, biologics and vaccines. Despite widespread interest, the literature lacks a defined …

This paper describes the production, purification, and immobilization of l-asparaginase II
(ASNase II) in chitosan nanoparticles (CSNPs). ASNase II is an effective antineoplastic …

In this study a novel kind of porous poly (l-glutamic acid)(PLGA)/chitosan polyelectrolyte
complex (PEC) microsphere was developed through electrostatic interaction between PLGA …

A synthetic mimic of viral structure has been constructed by the synergistic co-assembly of a
16-amino acid peptide and plasmid DNA. The rational design of this short peptide, including …