Histamine, which is synthesized by histidine decarboxylase (HDC), does not only modulate
the immune system, but is also acting as a neurotransmitter. Histaminergic neurons project …

Besides acting in the immune system, histamine is also a neurotransmitter in the central
nervous system. The H 1 R causes central side effects, eg of first generation antihistamines …

Background and Purpose This study aimed to investigate the relationship between the
plasma concentration (PK) of the novel histamine H3 receptor antagonist, GSK239512, and …

Glioblastomas (GBMs) are highly aggressive, invasive brain tumors with bad prognosis and
unmet medical need. These tumors are heterogeneous being constituted by a variety of cells …

В ходе доклинических и клинических исследований препаратов (ренгалин, эргоферон),
содержащих релиз-активные (Р-А) антитела к гистамину, была подтверждена их …

Aims The diverse physiological functions of histamine are mediated through distinct
histamine receptors. In this study we investigated the role of H 2 R and H 4 R in the effects of …

Transition-metal-free chemo-and stereoselective addition of 5-aminoindole (1a), tryptamine
(1b), and histamine (1c) to alkynes 2a–s to synthesize the indolyl/imidazolyl enamines 3a–p …

The inflammatory response caused by scorpion venoms is a key event in the pathogenesis
of scorpion envenomation. This response was assessed in the cardiac, pulmonary, and …

The histamine 4 receptor (H 4 R) is expressed primarily on cells involved in inflammation
and immune responses. Despite much research into inflammatory diseases, no drugs with …

Background Histamine (HA) regulates the sleep-wake cycle, synaptic plasticity and memory
in adult mammals. Dopaminergic specification in the embryonic ventral midbrain (VM) …