Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's …
Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disease
caused by an increase in the number of polyglutamine residues in the huntingtin (Htt) …
caused by an increase in the number of polyglutamine residues in the huntingtin (Htt) …
Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A
KP Bhat, S Yan, CE Wang, S Li… - Proceedings of the …, 2014 - National Acad Sciences
Ubiquitination of misfolded proteins, a common feature of many neurodegenerative
diseases, is mediated by different lysine (K) residues in ubiquitin and alters the levels of …
diseases, is mediated by different lysine (K) residues in ubiquitin and alters the levels of …
Differential changes in postsynaptic density proteins in postmortem Huntington's disease and Parkinson's disease human brains
C Fourie, E Kim, H Waldvogel, JM Wong… - Journal of …, 2014 - Wiley Online Library
NMDA and AMPA‐type glutamate receptors and their bound membrane‐associated
guanylate kinases (MAGUKs) are critical for synapse development and plasticity. We …
guanylate kinases (MAGUKs) are critical for synapse development and plasticity. We …
YAC128 Huntington׳ s disease transgenic mice show enhanced short-term hippocampal synaptic plasticity early in the course of the disease
M Ghilan, CA Bostrom, BN Hryciw, JM Simpson… - Brain research, 2014 - Elsevier
Huntington׳ s disease (HD) is a progressive and fatal neurodegenerative disorder caused by
a polyglutamine expansion in the gene encoding the protein huntingtin. The disease …
a polyglutamine expansion in the gene encoding the protein huntingtin. The disease …
Single-cell suspension methodology favors survival and vascularization of fetal striatal grafts in the YAC128 mouse model of Huntington's disease
G Cisbani, M Saint-Pierre, F Cicchetti - Cell Transplantation, 2014 - journals.sagepub.com
Cell replacement therapies have yielded variable and short-lived benefits in Huntington's
disease (HD) patients. This suboptimal outcome is likely due to the fact that graft survival is …
disease (HD) patients. This suboptimal outcome is likely due to the fact that graft survival is …
The role of palmitoylation in the pathogenesis of Huntington disease
SSF Sanders - 2014 - open.library.ubc.ca
Huntington disease (HD) is caused by a CAG expansion in HTT characterized by motor,
cognitive, and psychiatric disturbances. Huntingtin Interacting Protein 14 (HIP14) and HIP14 …
cognitive, and psychiatric disturbances. Huntingtin Interacting Protein 14 (HIP14) and HIP14 …
MEASUREMENTS OF DOPAMINE RELEASE AND UPTAKE IN HUNTINGTON'S DISEASE MODEL RODENTS
SV Kaplan, SC Fowler… - Compendium Of In Vivo …, 2014 - books.google.com
Huntington's disease (HD) is an autosomal dominant, neurodegenerative, movement
disorder that is characterized by motor dysfunction, altered behavior, and cognitive …
disorder that is characterized by motor dysfunction, altered behavior, and cognitive …
Stem cell derived monkey neural progenitor cells as a platform for translational research in Huntington's disease
RL Carter III - 2014 - search.proquest.com
Huntington's disease (HD) is a dominantly inherited, neurodegenerative disorder caused by
the expansion of glutamine residues in the N-terminal region of the huntingtin (HTT) protein …
the expansion of glutamine residues in the N-terminal region of the huntingtin (HTT) protein …
[PDF][PDF] Cell Replacement Therapy for Huntington's Disease: What We Have Learned from Post-mortem Analyses of Grafted Patients and Mice Models
G Cisbani - 2014 - collectionscanada.gc.ca
Huntington‟ s disease (HD) is a devastating autosomal dominant neurodegenerative
disorder which manifests because of a mutation in the huntingtin gene. It is characterized by …
disorder which manifests because of a mutation in the huntingtin gene. It is characterized by …
[引用][C] Mechanisms and efficacy of immunomodulatory therapies: neuroprotective effects in chronic inflammatory and degenerative diseases of the central nervous …
C Reick - 2014 - Dissertation, Bochum, Ruhr …