Current advances in the fabrication of microneedles for transdermal delivery
The transdermal route is an excellent site for drug delivery due to the avoidance of gastric
degradation and hepatic metabolism, in addition to easy accessibility. Although offering …
degradation and hepatic metabolism, in addition to easy accessibility. Although offering …
The role of microneedles for drug and vaccine delivery
HL Quinn, MC Kearney, AJ Courtenay… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Transdermal drug delivery offers a number of advantages for the patient, not
only due to its non-invasive and convenient nature, but also due to factors such as …
only due to its non-invasive and convenient nature, but also due to factors such as …
[HTML][HTML] Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight …
We describe formulation and evaluation of novel dissolving polymeric microneedle (MN)
arrays for the facilitated delivery of low molecular weight, high dose drugs. Ibuprofen sodium …
arrays for the facilitated delivery of low molecular weight, high dose drugs. Ibuprofen sodium …
Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease
K Matsuo, H Okamoto, Y Kawai, YS Quan… - Journal of …, 2014 - Elsevier
Vaccine therapy for Alzheimer's disease (AD) based on the amyloid cascade hypothesis has
recently attracted attention for treating AD. Injectable immunization using amyloid β peptide …
recently attracted attention for treating AD. Injectable immunization using amyloid β peptide …
[HTML][HTML] Microneedle/nanoencapsulation-mediated transdermal delivery: Mechanistic insights
YA Gomaa, MJ Garland, FJ McInnes… - European Journal of …, 2014 - Elsevier
A systematic study was undertaken to gain more insight into the mechanism of transdermal
delivery of nanoencapsulated model dyes across microneedle (MN)-treated skin, a complex …
delivery of nanoencapsulated model dyes across microneedle (MN)-treated skin, a complex …
Skin immunization with influenza vaccines
I Skountzou, RW Compans - Influenza Pathogenesis and Control-Volume II, 2014 - Springer
Problems with existing influenza vaccines include the strain specificity of the immune
response, resulting in the need for frequent reformulation in response to viral antigenic drift …
response, resulting in the need for frequent reformulation in response to viral antigenic drift …
Evaluation of the effect of polymeric microneedle arrays of varying geometries in combination with a high-velocity applicator on skin permeability and irritation
T Watanabe, K Hagino, T Sato - Biomedical microdevices, 2014 - Springer
Polymeric microneedles offer the advantages of being both mass-producible and
inexpensive. However, their weakness lies in the fact that they are not adequate for sharp …
inexpensive. However, their weakness lies in the fact that they are not adequate for sharp …
A protective role of murine langerin+ cells in immune responses to cutaneous vaccination with microneedle patches
JA Pulit-Penaloza, ES Esser, EV Vassilieva, JW Lee… - Scientific reports, 2014 - nature.com
Cutaneous vaccination with microneedle patches offers several advantages over more
frequently used approaches for vaccine delivery, including improved protective immunity …
frequently used approaches for vaccine delivery, including improved protective immunity …