Current advances in the fabrication of microneedles for transdermal delivery

S Indermun, R Luttge, YE Choonara, P Kumar… - Journal of controlled …, 2014 - Elsevier
The transdermal route is an excellent site for drug delivery due to the avoidance of gastric
degradation and hepatic metabolism, in addition to easy accessibility. Although offering …

The role of microneedles for drug and vaccine delivery

HL Quinn, MC Kearney, AJ Courtenay… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Transdermal drug delivery offers a number of advantages for the patient, not
only due to its non-invasive and convenient nature, but also due to factors such as …

[HTML][HTML] Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight …

MTC McCrudden, AZ Alkilani, CM McCrudden… - Journal of Controlled …, 2014 - Elsevier
We describe formulation and evaluation of novel dissolving polymeric microneedle (MN)
arrays for the facilitated delivery of low molecular weight, high dose drugs. Ibuprofen sodium …

Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease

K Matsuo, H Okamoto, Y Kawai, YS Quan… - Journal of …, 2014 - Elsevier
Vaccine therapy for Alzheimer's disease (AD) based on the amyloid cascade hypothesis has
recently attracted attention for treating AD. Injectable immunization using amyloid β peptide …

[HTML][HTML] Microneedle/nanoencapsulation-mediated transdermal delivery: Mechanistic insights

YA Gomaa, MJ Garland, FJ McInnes… - European Journal of …, 2014 - Elsevier
A systematic study was undertaken to gain more insight into the mechanism of transdermal
delivery of nanoencapsulated model dyes across microneedle (MN)-treated skin, a complex …

Skin immunization with influenza vaccines

I Skountzou, RW Compans - Influenza Pathogenesis and Control-Volume II, 2014 - Springer
Problems with existing influenza vaccines include the strain specificity of the immune
response, resulting in the need for frequent reformulation in response to viral antigenic drift …

Evaluation of the effect of polymeric microneedle arrays of varying geometries in combination with a high-velocity applicator on skin permeability and irritation

T Watanabe, K Hagino, T Sato - Biomedical microdevices, 2014 - Springer
Polymeric microneedles offer the advantages of being both mass-producible and
inexpensive. However, their weakness lies in the fact that they are not adequate for sharp …

A protective role of murine langerin+ cells in immune responses to cutaneous vaccination with microneedle patches

JA Pulit-Penaloza, ES Esser, EV Vassilieva, JW Lee… - Scientific reports, 2014 - nature.com
Cutaneous vaccination with microneedle patches offers several advantages over more
frequently used approaches for vaccine delivery, including improved protective immunity …

[引用][C] 阿魏酸的微针透皮给药研究

杨冰, 杜守颖, 白洁, 尚可心, 陆洋, 李鹏跃 - 中国中药杂志, 2014