Protein production using the baculovirus‐insect cell expression system

A Contreras‐Gómez, A Sánchez‐Mirón… - Biotechnology …, 2014 - Wiley Online Library
The baculovirus‐insect cell expression system is widely used in producing recombinant
proteins. This review is focused on the use of this expression system in developing …

Cellular targets for improved manufacturing of virus-based biopharmaceuticals in animal cells

AF Rodrigues, MJT Carrondo, PM Alves… - Trends in …, 2014 - cell.com
The past decade witnessed the entry into the market of new virus-based biopharmaceuticals
produced in animal cells such as oncolytic vectors, virus-like particle vaccines, and gene …

Transcriptome responses of the host Trichoplusia ni to infection by the baculovirus Autographa californica multiple nucleopolyhedrovirus

YR Chen, S Zhong, Z Fei, S Gao, S Zhang, Z Li… - Journal of …, 2014 - Am Soc Microbiol
Productive infection of Trichoplusia ni cells by the baculovirus Autographa californica
multiple nucleopolyhedrovirus (AcMNPV) leads to expression of∼ 156 viral genes and …

[图书][B] Large-scale networks in engineering and life sciences

P Benner, R Findeisen, D Flockerzi, U Reichl… - 2014 - Springer
Modeling, analysis, and control of complex large-scale systems are becoming increasingly
important. Large-scale systems are often the result of networked interactions among an …

Metabolic profiling of insect cell lines: Unveiling cell line determinants behind system's productivity

F Monteiro, V Bernal, X Saelens… - Biotechnology and …, 2014 - Wiley Online Library
Baculovirus infection boosts the host biosynthetic activity towards the production of viral
components and the recombinant protein of interest, hyper‐productive phenotypes being the …

[HTML][HTML] Enhanced expression of full-length human cytomegalovirus fusion protein in non-swelling baculovirus-infected cells with a minimal fed-batch strategy

M Patrone, N Carinhas, MQ Sousa, C Peixoto… - PLoS …, 2014 - journals.plos.org
Human cytomegalovirus congenital infection represents an unmet medical issue and
attempts are ongoing to develop an effective vaccine. The virion fusion players of this …

Hybrid modeling for systems biology: Theory and practice

M von Stosch, N Carinhas, R Oliveira - Large-Scale Networks in …, 2014 - Springer
Whereas bottom-up systems biology relies primarily on parametric mathematical models,
which try to infer the system behavior from a priori specified mechanisms, top-down systems …

Metabolic Flux Analysis Tools to Investigate Brain Metabolism In Vitro

AI Amaral, PM Alves, AP Teixeira - Brain energy metabolism, 2014 - Springer
In recent decades, 13 C nuclear magnetic resonance (NMR) spectroscopy and metabolic
modeling tools allowed estimating the main cerebral metabolic fluxes in vitro and in vivo …

[PDF][PDF] Modellbasierte Identifizierung von Interventionsstrategien für Stoffwechselnetzwerke

O Hädicke - 2014 - pure.mpg.de
Kurzzusammenfassung Mit Hilfe der industriellen Biotechnologie können eine Vielzahl
verschiedener Substanzen durch den Einsatz geeigneter, evtl. modifizierter …

[PDF][PDF] Introduction to insect molecular biology

F Zhu, EY Park, BB Patnaik - researchgate.net
Entomology now is a diversified science discipline, deviating considerably from the
incorporated principles of Molecular biology, Genetics and Biochemistry. It has provided …