Background: Deaths due to prescription opioid overdoses have increased dramatically. High-
quality guidelines could help clinicians mitigate risks associated with opioid therapy …

Patients requiring chronic opioid therapy may not respond to or tolerate the first opioid
prescribed to them, necessitating rotation to another opioid. They may also require dose …

There has been a need for a brief assessment tool to determine compliance with use of
prescribed opioids for pain. The purpose of this study was to develop and begin the …

Objective: NSAIDs, such as diclofenac, are the most commonly used medications to treat
osteoarthritis (OA), but they are associated with dose-related adverse events (AEs). Low …

In selected patients with chronic non‐malignant pain, chronic opioid therapy is indicated.
Published guidelines recommend long‐acting over short‐acting opioids in these patients …

Prescription medication abuse has become a national epidemic. In 2011, more than 238
million narcotic analgesic prescriptions were written, with more attributable deaths than …

Objective: Opioid analgesics are commonly and increasingly prescribed by physicians for
the management of chronic pain. However, strong evidence supports the need for strategies …

Background: For properly selected patients experiencing chronic pain, extended-release
opioid formulations may represent an appropriate pain management choice. For the many …

Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy found mainly in
populations of African and Mediterranean descent, including approximately 100,000 …

Introduction Pain—including acute or persistent acute pain—is a common condition that is
increasingly being treated with opioids in the United States. The acute pain treatment setting …