Here we review cell cycle control in the fission yeast, Schizosaccharomyces pombe, in
response to an abrupt reduction of glucose concentration in culture media. S. pombe arrests …

Accurate replication of the genome requires the evolutionarily conserved minichromosome
maintenance protein, Mcm10. Although the details of the precise role of Mcm10 in DNA …

Meiotic recombination normally takes place between allelic sequences on homologs. This
process can also occur between non-allelic homologous sequences. Such ectopic …

Oxidative DNA damage is repaired primarily by the base excision repair (BER) pathway in a
process initiated by removal of base lesions or mismatched bases by DNA glycosylases …

To characterize proteins that interact with single-stranded/double-stranded (ss/ds) DNA
junctions in whole cell free extracts of Saccharomyces cerevisiae, we used [32 P]-labeled …

Abstract Background Human MutY glycosylase homolog (hMYH), a component of the base
excision repair pathway, is responsible for the generation of apurinic/apyrimidinic sites …

The primary function of the lung is to facilitate the exchange of oxygen and carbon dioxide
between air and blood and to exclude or defend against infectious agents and other …

As described in the “1.6. 4 TopBP1 dependent ATR activation” section TopBP1 (the Rad4
homolog) in higher eukaryotes has been shown able to directly activate ATRs kinase activity …

The genetic control of longevity and pro-longevity phenotypes is likely to be determined by
subtle variations in many genes involved in multiple genetic pathways. The challenge is to …

Genomic integrity is preserved by checkpoints, which are signal transduction pathways that
serve to delay cell cycle progression in the presence of DNA damage or replication stress …