Background Determining etiological factors and reviewing advances in diagnostic
modalities sensitive and specific to Major Depressive Disorder (MDD) is of importance in its …

Stressful events have been implicated in the evolution of mood disorders. In addition to brain
neurotransmitters and growth factors, the view has been offered that these disorders might …

Psychological stress-related processes are thought to contribute to the development and
progression of type 2 diabetes, but the biological mechanisms involved are poorly …

Patients, clinicians, researchers, and the general public commonly assume that depression
is inexorably intertwined with the material and social worlds of the person with depression …

1 King's College London Institute of Psychiatry, Psychology and Neuroscience, London, UK
2 Department of Psychiatry, University of Zimbabwe College of Health Sciences, Harare …

The course of depression in relation to myocardial infarction (MI), commonly known as heart
attack, and the consequences for mortality are not well characterized. Further, optimism may …

Although exposure to a recent major life event is one of the strongest known risk factors for
depression, many people who experience such stress do not become depressed. Moreover …

Approaching the inverse association between perceived discrimination and close
relationship functioning from a stress and coping framework, we propose and test a novel …

Immune dysfunction and pro-inflammatory states in particular have been implicated in the
aetiology and pathogenesis of depression. Whilst the onset of an episode and certain …

There is now abundant evidence that the immune system and the brain have close
functional interactions in both directions. This review focuses on the influence of the …