Presynaptic long-term depression mediated by Gi/o-coupled receptors

BK Atwood, DM Lovinger, BN Mathur - Trends in neurosciences, 2014 - cell.com
Long-term depression (LTD) of the efficacy of synaptic transmission is now recognized as an
important mechanism for the regulation of information storage and the control of actions, as …

[HTML][HTML] Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

W Wang, MR Whorton, R MacKinnon - Elife, 2014 - elifesciences.org
GIRK channels control spike frequency in atrial pacemaker cells and inhibitory potentials in
neurons. By directly responding to G proteins, PIP2 and Na+, GIRK is under the control of …

Firing modes of dopamine neurons drive bidirectional GIRK channel plasticity

AL Lalive, MB Munoz, C Bellone… - Journal of …, 2014 - Soc Neuroscience
G-protein-coupled inwardly rectifying potassium (GIRK) channels contribute to the resting
membrane potential of many neurons, including dopamine (DA) neurons in the ventral …

Effects of the selective KACh channel blocker NTC-801 on atrial fibrillation in a canine model of atrial tachypacing: comparison with class Ic and III drugs

W Yamamoto, N Hashimoto, J Matsuura… - Journal of …, 2014 - journals.lww.com
The present study examines the effects of NTC-801, a highly selective acetylcholine (ACh)
receptor-activated potassium (K ACh) channel blocker, on atrial fibrillation (AF) in a canine …

[PDF][PDF] Henry A. Lester

K Hartline, F Ratliff, I Channels - physiology.case.edu
4. Lester, HA (1972) Vulnerability of desensitized or curare-treated acetylcholine receptors
to irreversible blockade by cobra toxin. Mol. Pharmacol. 8, 632-644. 5. Lester, HA …

[图书][B] Gβγ acts at an inter-subunit cleft to activate GIRK1 channels

R Mahajan - 2014 - search.proquest.com
Heterotrimeric guanine nucleotide-binding proteins (G-proteins) consist of an alpha subunit
(G&agr;) and the dimeric beta-gamma subunit (Gβγ). The first example of direct cell …

A novel, radiolabel-free pulse chase strategy for studying Kir3-Gßy assembly and trafficking

P Zylbergold - 2014 - escholarship.mcgill.ca
Kir3 channels are essential regulators of neuronal and cardiac excitability, maintaining cells
at their resting membrane potentials. While much research has been dedicated to …