Immunological and technical considerations in application of alginate-based microencapsulation systems
GA Paredes Juárez, M Spasojevic, MM Faas… - … in bioengineering and …, 2014 - frontiersin.org
Islets encapsulated in immunoprotective microcapsules are being proposed as an
alternative for insulin therapy for treatment of type 1 diabetes. Many materials for producing …
alternative for insulin therapy for treatment of type 1 diabetes. Many materials for producing …
Toll-like receptors in Alzheimer's disease: a therapeutic perspective
ME Gambuzza, V Sofo, FM Salmeri… - CNS & Neurological …, 2014 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disorder mainly characterized by amyloid-
β (Aβ) plaques, neurofibrillary tangles, loss of synapses and neurons and chronic …
β (Aβ) plaques, neurofibrillary tangles, loss of synapses and neurons and chronic …
[HTML][HTML] Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without …
PO Ilyinskii, CJ Roy, CP O'Neil, EA Browning, LA Pittet… - Vaccine, 2014 - Elsevier
Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and
by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic …
by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic …
Toll-like receptor agonists: a patent review (2011–2013)
WM Hussein, TY Liu, M Skwarczynski… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Toll-like receptors (TLRs) are a crucial part of the innate immunity and present
the first line of defense against pathogens. In humans, there are ten TLRs, with TLR3, 7, 8 …
the first line of defense against pathogens. In humans, there are ten TLRs, with TLR3, 7, 8 …
Small molecule glutaminase inhibitors block glutamate release from stimulated microglia
AG Thomas, CM O'Driscoll, J Bressler… - Biochemical and …, 2014 - Elsevier
Glutaminase plays a critical role in the generation of glutamate, a key excitatory
neurotransmitter in the CNS. Excess glutamate release from activated macrophages and …
neurotransmitter in the CNS. Excess glutamate release from activated macrophages and …
Understanding and modulating the Toll like Receptors (TLRs) and NOD like Receptors (NLRs) cross talk in type 2 diabetes
B Prajapati, P Kumar Jena, P Rajput… - Current diabetes …, 2014 - ingentaconnect.com
Obesity and Type 2 diabetes are leading health problems which are characterized by low-
grade inflammation with an increase in inflammatory cytokines along with the change in the …
grade inflammation with an increase in inflammatory cytokines along with the change in the …
Toll-like receptors in lymphoid malignancies: double-edged sword
Toll-like receptors (TLRs) are the best characterized pattern recognition receptors (PRRs),
which play an essential role in the recognition of invading pathogens via specific microbial …
which play an essential role in the recognition of invading pathogens via specific microbial …
Structural aspects of molecular recognition in the immune system. Part II: Pattern recognition receptors (IUPAC Technical Report)
JA Robinson, K Moehle - Pure and Applied Chemistry, 2014 - degruyter.com
The vertebrate immune system uses pattern recognition receptors (PRRs) to detect a large
variety of molecular signatures (pathogen-associated molecular patterns, PAMPs) from a …
variety of molecular signatures (pathogen-associated molecular patterns, PAMPs) from a …