Typically, Parkinson's disease (PD) is the second most prevalent neurodegenerative
disease in ageing individuals. It is now clear that genetic susceptibility and environmental …

Subsets of rodent neurons are reported to express major histocompatibility complex class I
(MHC-I), but such expression has not been reported in normal adult human neurons. Here …

Significance: Parkinson's disease (PD) is no longer considered merely a movement disorder
caused by degeneration of dopamine neurons in the midbrain. It is now recognized as a …

Parkinson disease (PD) is an α-synucleinopathy resulting in the preferential loss of highly
vulnerable dopamine (DA) substantia nigra (SN) neurons. Mutations (eg, A53T) in the α …

Mutations affecting mitochondrial complex I, a multi-subunit assembly that couples electron
transfer to proton pumping, are the most frequent cause of heritable mitochondrial diseases …

Dopaminergic (DA) neurons in the ventral mesodiencephalon control locomotion and
emotion and are affected in psychiatric and neurodegenerative diseases, such as …

Stromal interaction molecule (STIM) proteins are parts of elaborate eukaryotic Ca2+
signaling systems and are considered to be important players in regulating neuronal Ca2+ …

Neurodegeneration of cholinergic and dopaminergic neurons is a major hallmark in
Alzheimer׳ s or Parkinson׳ s disease, respectively. A dysregulation in calcium homeostasis …

The impairment of protein degradation via the ubiquitin‐proteasome system (UPS) is
present in sporadic Parkinson's disease (PD), and might play a key role in selective …

Around the globe, chemical compounds are used to treat or repel pests and plagues that
pose a threat to food and feed production. From epidemiological studies, it is known that …