Solid organ transplantation is a vital therapy for end stage diseases. Decades of research
have established that components of the adaptive immune system are critical for transplant …

Highlights•Sterile necrotic cell death induces acute inflammatory response.•Macrophages
sense the danger signals from dead cells and induce IL-1α.•IL-1α also serves as a primary …

Spontaneous or medically induced reperfusion occurs in up to 70% of patients within 24 h
after cerebral ischemia. Reperfusion of ischemic brain tissue can augment the inflammatory …

Acute kidney injury (AKI) is a common problem in the hospital setting and intensive care unit.
Despite improved understanding, there are no effective therapies available to treat AKI. A …

Polymorphonuclear leukocyte (PMN)-mediated acute lung injury from ischemia/reperfusion
(I/R) remains a major cause of morbidity and mortality in critical care medicine. Here, we …

The syntheses of inflammatory mediators are energy-intensive processes and the
mitochondria play pivotal roles in supporting these energy-requiring molecular responses. In …

YKL-40 is a secreted glycoprotein, which is a shared biomarker of chronic inflammation and
oncogenic transformation. Indeed, YKL-40 expression is up-regulated in many diseases …

Dendritic cells are central orchestrators of the immune response. They communicate with
both innate and adaptive immune systems and can aggravate or attenuate renal …

Aos meu amigos do laboratório de Imunofarmacologia: Camila, Mari Morato, Francisco,
Matheus, Mari Koga, Mateus, Edson, Junior, Raquel, Marlise e Silvana–pelo …

Polymorphonuclear leukocyte (PMN)-mediated acute lung injury from ischemia/reperfusion
(I/R) remains a major cause of morbidity and mortality in critical care medicine. Here, we …