Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis

JE Lee, K Ge - Cell & bioscience, 2014 - Springer
The nuclear receptor PPARγ is a master regulator of adipogenesis. PPARγ is highly
expressed in adipose tissues and its expression is markedly induced during adipogenesis …

Molecular targets of aspirin and cancer prevention

L Alfonso, G Ai, RC Spitale, GJ Bhat - British journal of cancer, 2014 - nature.com
Salicylates from plant sources have been used for centuries by different cultures to treat a
variety of ailments such as inflammation, fever and pain. A chemical derivative of salicylic …

Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation

ML Kuhn, B Zemaitaitis, LI Hu, A Sahu, D Sorensen… - PloS one, 2014 - journals.plos.org
The emerging view of Nε-lysine acetylation in eukaryotes is of a relatively abundant post-
translational modification (PTM) that has a major impact on the function, structure, stability …

[HTML][HTML] Role of epithelial-mesenchymal transition in gastric cancer initiation and progression

Z Peng, CX Wang, EH Fang, GB Wang… - World Journal of …, 2014 - ncbi.nlm.nih.gov
Gastric cancer is one of the most common malignant tumors worldwide. Due to its intricate
initiation and progression mechanisms, early detection and effective treatment of gastric …

[HTML][HTML] Genome of brown tide virus (AaV), the little giant of the Megaviridae, elucidates NCLDV genome expansion and host–virus coevolution

M Moniruzzaman, GR LeCleir, CM Brown, CJ Gobler… - Virology, 2014 - Elsevier
Aureococcus anophagefferens causes economically and ecologically destructive “brown
tides” in the United States, China and South Africa. Here we report the 370,920 bp genomic …

Crafting the brain–role of histone acetyltransferases in neural development and disease

BN Sheikh - Cell and tissue research, 2014 - Springer
The human brain is a highly specialized organ containing nearly 170 billion cells with
specific functions. Development of the brain requires adequate proliferation, proper cell …

The UmGcn5 gene encoding histone acetyltransferase from Ustilago maydis is involved in dimorphism and virulence

JM González-Prieto, R Rosas-Quijano… - Fungal Genetics and …, 2014 - Elsevier
We isolated a gene encoding a histone acetyltransferase from Ustilago maydis (DC.) Cda.,
which is orthologous to the Saccharomyces cerevisiae GCN5 gene. The gene was isolated …

Neural crest development and craniofacial morphogenesis is coordinated by nitric oxide and histone acetylation

Y Kong, M Grimaldi, E Curtin, M Dougherty… - Chemistry & biology, 2014 - cell.com
Cranial neural crest (CNC) cells are patterned and coalesce to facial prominences that
undergo convergence and extension to generate the craniofacial form. We applied a …

Proteolytic clipping of histone tails: the emerging role of histone proteases in regulation of various biological processes

GK Azad, RS Tomar - Molecular biology reports, 2014 - Springer
Chromatin is a dynamic DNA scaffold structure that responds to a variety of external and
internal stimuli to regulate the fundamental biological processes. Majority of the cases …

Multiple Complexes of Long Aliphatic N-Acyltransferases Lead to Synthesis of 2,6-Diacylated/2-Acyl-Substituted Glycopeptide Antibiotics, Effectively Killing …

SY Lyu, YC Liu, CY Chang, CJ Huang… - Journal of the …, 2014 - ACS Publications
Teicoplanin A2-2 (Tei)/A40926 is the last-line antibiotic to treat multidrug-resistant Gram-
positive bacterial infections, eg, methicillin-resistant Staphylococcus aureus (MRSA) and …