Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical …
S Schenone, M Radi, F Musumeci, C Brullo… - Chemical …, 2014 - ACS Publications
1. INTRODUCTION Nitrogen-containing heterocycles are widely distributed in nature and
essential for life, playing a vital role in the metabolism of all living cells. Among the many …
essential for life, playing a vital role in the metabolism of all living cells. Among the many …
The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin
C Soica, C Oprean, F Borcan, C Danciu… - Molecules, 2014 - mdpi.com
Oleanolic and ursolic acids are natural triterpenic compounds with pentacyclic cholesterol-
like structures which gives them very low water solubility, a significant disadvantage in terms …
like structures which gives them very low water solubility, a significant disadvantage in terms …
Inhibitory effect of Angelica sinensis extract in the presence of 2-hydroxypropyl-β-cyclodextrin
Angelica sinensis (AS) is a traditional Chinese medicinal herb. Its ethanolic extract contains
active ingredients, such as ferulic acid, ligustilide, and butylidenephthalide, which are …
active ingredients, such as ferulic acid, ligustilide, and butylidenephthalide, which are …
[HTML][HTML] Preparation, physicochemical characterization and in-vitro dissolution studies of diosmin-cyclodextrin inclusion complexes
F Ai, Y Ma, J Wang, Y Li - Iranian Journal of Pharmaceutical …, 2014 - ncbi.nlm.nih.gov
Diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption
is limited by its extremely low dissolution rate. In this study, β-cyclodextrin (βCD) and 2 …
is limited by its extremely low dissolution rate. In this study, β-cyclodextrin (βCD) and 2 …
Synthesis of new pyrazole and antibacterial pyrazolopyrimidine derivatives
A Rahmouni, A Romdhane, AB Said… - Turkish Journal of …, 2014 - journals.tubitak.gov.tr
Substituted-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4-amines 2a--c were synthesized by
treating 5-aminopyrazole-4-carbonitriles 1a--c with formamide. The reactivity of compounds …
treating 5-aminopyrazole-4-carbonitriles 1a--c with formamide. The reactivity of compounds …
A 5, 7-dimethoxyflavone/hydroxypropyl-β-cyclodextrin inclusion complex with anti-butyrylcholinesterase activity
S Songngam, M Sukwattanasinitt, K Siralertmukul… - AAPS …, 2014 - Springer
This study aimed to improve the water solubility of 5, 7-dimethoxyflavone (5, 7-DMF) isolated
from Kaempferia parviflora by complexation with 2-hydroxypropyl-β-cyclodextrin (HPβ-CD) …
from Kaempferia parviflora by complexation with 2-hydroxypropyl-β-cyclodextrin (HPβ-CD) …