Multiple sclerosis genetics
S Sawcer, RJM Franklin, M Ban - The Lancet Neurology, 2014 - thelancet.com
Genome-wide association studies have revolutionised the genetic analysis of multiple
sclerosis. Through international collaborative efforts involving tens of thousands of cases …
sclerosis. Through international collaborative efforts involving tens of thousands of cases …
Genome-wide association studies: findings at the major histocompatibility complex locus in psychosis
The major histocompatibility complex (MHC) is one of the most intensively investigated,
genetically diverse regions of the genome. In its extended form, it encodes more than 400 …
genetically diverse regions of the genome. In its extended form, it encodes more than 400 …
Integrating mapping-, assembly-and haplotype-based approaches for calling variants in clinical sequencing applications
High-throughput DNA sequencing technology has transformed genetic research and is
starting to make an impact on clinical practice. However, analyzing high-throughput …
starting to make an impact on clinical practice. However, analyzing high-throughput …
[HTML][HTML] HIBAG—HLA genotype imputation with attribute bagging
Genotyping of classical human leukocyte antigen (HLA) alleles is an essential tool in the
analysis of diseases and adverse drug reactions with associations mapping to the major …
analysis of diseases and adverse drug reactions with associations mapping to the major …
[HTML][HTML] Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes
Psoriasis vulgaris (PsV) risk is strongly associated with variation within the major
histocompatibility complex (MHC) region, but its genetic architecture has yet to be fully …
histocompatibility complex (MHC) region, but its genetic architecture has yet to be fully …
[HTML][HTML] Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis
MD Mayes, L Bossini-Castillo, O Gorlova… - The American Journal of …, 2014 - cell.com
In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with
the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human …
the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human …
[HTML][HTML] Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets
Genetic and epigenetic mechanisms may interact and together affect biological processes
and disease development. However, most previous studies have investigated genetic and …
and disease development. However, most previous studies have investigated genetic and …
[HTML][HTML] HLA Diversity in the 1000 Genomes Dataset
PA Gourraud, P Khankhanian, N Cereb, SY Yang… - PloS one, 2014 - journals.plos.org
The 1000 Genomes Project aims to provide a deep characterization of human genome
sequence variation by sequencing at a level that should allow the genome-wide detection of …
sequence variation by sequencing at a level that should allow the genome-wide detection of …
[HTML][HTML] Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells
FJ Hartmann, M Khademi, J Aram, S Ammann… - Nature …, 2014 - nature.com
Genome-wide association studies implicate dysregulation of immune mechanisms in the
pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T …
pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T …
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations
Previous studies have emphasized ethnically heterogeneous human leukocyte antigen
(HLA) classical allele associations to rheumatoid arthritis (RA) risk. We fine-mapped RA risk …
(HLA) classical allele associations to rheumatoid arthritis (RA) risk. We fine-mapped RA risk …