Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets

C Spitzweg, KC Bible, LC Hofbauer… - The lancet Diabetes & …, 2014 - thelancet.com
Approximately 30% of patients with advanced, metastatic differentiated thyroid cancer have
radioiodine-refractory disease, based on decreased expression of the sodium iodide …

[PDF][PDF] Guidelines for the management of thyroid cancer.

P Perros, K Boelaert, S Colley, C Evans… - Clinical …, 2014 - thyroidcancercanada.org
BTA_Guidelines_for_the_Management_of_Thyroid Cancer_E Page 1 CLINICAL
ENDOCRINOLOGY VOLUME 81 SUPPLEMENT 1 JULY 2014 THE CLINICAL JOURNAL OF …

The current role of targeted therapies to induce radioiodine uptake in thyroid cancer

E Fröhlich, R Wahl - Cancer treatment reviews, 2014 - Elsevier
Targeted therapy pinpointing specific alteration in cancer cells has gained an important role
in the treatment of cancer. Compounds that re-induce thyroid-specific functions could be …

Support of a bi-faceted role of estrogen receptor β (ERβ) in ERα-positive breast cancer cells

P Jonsson, A Katchy, C Williams - Endocrine-related cancer, 2014 - erc.bioscientifica.com
[131 I] meta-iodobenzylguanidine ([131 I] MIBG) is the most commonly used treatment for
metastatic pheochromocytoma and paraganglioma. It enters the chromaffin cells via the …

Differentiated thyroid cancer—personalized therapies to prevent overtreatment

M Luster, T Weber, FA Verburg - Nature Reviews Endocrinology, 2014 - nature.com
The concept of individualized therapy is rapidly gaining recognition in the management of
patients with differentiated thyroid cancer (DTC). This Review provides an overview of the …

Nuclear receptor expression in human differentiated thyroid tumors

M Mond, M Alexiadis, N Eriksson, MJ Davis… - Thyroid, 2014 - liebertpub.com
Background: Nuclear receptors (NRs) play a key role in endocrine signaling and metabolism
and are important therapeutic targets in a number of hormone-dependent malignancies …

The Na+/I− symporter (NIS) and thyroid hormone biosynthesis

JP Nicola, N Carrasco - Cellular Endocrinology in Health and Disease, 2014 - Elsevier
The thyroid hormones are essential for the development and maturation of the central
nervous system, lungs, and skeletal system, and for intermediary metabolism in virtually all …

Anomalies moléculaires de la voie MAPK et cancer papillaire de la thyroïde: étude de deux phosphatases spécifiques de ERK, DUSP5 et DUSP6

C Buffet - 2014 - theses.hal.science
Le cancer papillaire de la thyroïde (CPT) est la tumeur endocrine la plus fréquente. Des
anomalies moléculaires activant la voie des MAPK (Mitogen-Activated Protein Kinases) sont …

Actualités dans la prise en charge des cancers thyroïdiens de souche vésiculaire

J Abeillon-du Payrat, P Caron… - Annales d'endocrinologie, 2014 - Elsevier
Résumé Les nouvelles recommandations 2014 de l'American Thyroid Association sur la
prise en charge des cancers thyroïdiens de souche vésiculaire ont été présentées au …

Radiovirotherapy for the Treatment of Cancer

KJ Harrington - Novel Technologies for Vaccine Development, 2014 - Springer
This chapter focuses on the relatively narrow definition of radiovirotherapy as “the use of
viral vectors engineered to express genes that drive uptake of radioisotopes into cancer …