Proteostasis impairment in protein-misfolding and-aggregation diseases
Cells possess an extensive network of components to safeguard proteome integrity and
maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines …
maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines …
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
C Hetz, B Mollereau - Nature Reviews Neuroscience, 2014 - nature.com
The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …
A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease
Chaperones are central to the proteostasis network (PN) and safeguard the proteome from
misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 …
misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 …
The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …
level. First, the interactions between curcumin and its molecular targets are addressed on …
[HTML][HTML] Protein quality control and elimination of protein waste: The role of the ubiquitin–proteasome system
I Amm, T Sommer, DH Wolf - … et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
Mistakes are part of our world and constantly occurring. Due to transcriptional and
translational failures, genomic mutations or diverse stress conditions like oxidation or heat …
translational failures, genomic mutations or diverse stress conditions like oxidation or heat …
The role of protein clearance mechanisms in organismal ageing and age-related diseases
The ability to maintain a functional proteome, or proteostasis, declines during the ageing
process. Damaged and misfolded proteins accumulate with age, impairing cell function and …
process. Damaged and misfolded proteins accumulate with age, impairing cell function and …
Heavy metals and metalloids as a cause for protein misfolding and aggregation
While the toxicity of metals and metalloids, like arsenic, cadmium, mercury, lead and
chromium, is undisputed, the underlying molecular mechanisms are not entirely clear …
chromium, is undisputed, the underlying molecular mechanisms are not entirely clear …
Mechanisms of protein-folding diseases at a glance
JS Valastyan, S Lindquist - Disease models & mechanisms, 2014 - journals.biologists.com
For a protein to function appropriately, it must first achieve its proper conformation and
location within the crowded environment inside the cell. Multiple chaperone systems are …
location within the crowded environment inside the cell. Multiple chaperone systems are …
The mechanistic links between proteasome activity, aging and agerelated diseases
I Saez, D Vilchez - Current genomics, 2014 - ingentaconnect.com
Damaged and misfolded proteins accumulate during the aging process, impairing cell
function and tissue homeostasis. These perturbations to protein homeostasis (proteostasis) …
function and tissue homeostasis. These perturbations to protein homeostasis (proteostasis) …
HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy
X Wang, M Chen, J Zhou… - … journal of oncology, 2014 - spandidos-publications.com
Among the heat shock proteins (HSP), HSP27, HSP70 and HSP90 are the most studied
stress-inducible HSPs, and are induced in response to a wide variety of physiological and …
stress-inducible HSPs, and are induced in response to a wide variety of physiological and …