Rolling circle amplification (RCA) is an isothermal enzymatic process where a short DNA or
RNA primer is amplified to form a long single stranded DNA or RNA using a circular DNA …

Rare cells are low-abundance cells in a much larger population of background cells.
Conventional benchtop techniques have limited capabilities to isolate and analyze rare cells …

We present a facile approach to make aptamer‐conjugated FRET (fluorescent resonance
energy transfer) nanoflowers (NFs) through rolling circle replication for multiplexed cellular …

The potential utility of circulating tumor cells (CTCs) to guide clinical care in oncology
patients has gained momentum with emerging micro-and nanotechnologies. Establishing …

Individual proteins can now often be modified with atomic precision, but there are still major
obstacles to connecting proteins into larger assemblies. To direct protein assembly, ideally …

It has been more than 20 years since the first micro total analysis systems (μTAS) papers
were published. Initial reports of these devices, which are also commonly referred to as …

Sensitive detection of cancer cells plays a critically important role in the early detection of
cancer and cancer metastasis. However, because circulating tumor cells are extremely rare …

Nucleic acids display remarkable properties beyond information storage and propagation.
The well-understood base pairing rules have enabled nucleic acids to be assembled into …

Signal amplification strategies have attracted considerable attention due to the growing
demands for ultrasensitive bioassays. Here, we summarize the latest developments in the …

In this work, dynamic introduction of bioactive RGD peptide on a matrix was successfully
demonstrated via reversible multicovalent interactions within PBA/cis-diol polymeric …