TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus …

A Heurich, H Hofmann-Winkler, S Gierer… - Journal of …, 2014 - Am Soc Microbiol
The type II transmembrane serine proteases TMPRSS2 and HAT can cleave and activate
the spike protein (S) of the severe acute respiratory syndrome coronavirus (SARS-CoV) for …

Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells

A Milewska, M Zarebski, P Nowak, K Stozek… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT Human coronavirus NL63 (HCoV-NL63) is an alphacoronavirus that was first
identified in 2004 in the nasopharyngeal aspirate from a 7-month-old patient with a …

Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus

X Liu, N Yang, J Tang, S Liu, D Luo, Q Duan, X Wang - Virus research, 2014 - Elsevier
Abstract Influenza A (H1N1) virus, a high-risk infectious pathogen, can cause severe acute
lung injury leading to significant morbidity and mortality. Angiotensin-converting enzyme 2 …

Host Entry Factors for Human Coronaviruses

T Heald-Sargent - 2014 - ecommons.luc.edu
Coronaviruses infect a diverse range of animals from birds to pigs and cats to humans.
Coronaviruses employ RNA-based replicative processes and as such are genetically …

Bedeutung der ACE2-Spaltung durch Wirtszellproteasen für die SARS-Coronavirus-Infektion

A Heurich - 2014 - ediss.uni-goettingen.de
Das severe acute respiratory syndrome Coronavirus (SARS-CoV) ist ein hochpathogenes
Virus, dessen zoonotischer Eintrag in die Bevölkerung eine substantielle Gesundheitsgefahr …