Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …

Abstract The Biopharmaceutics Classification System (BCS) has found widespread utility in
drug discovery, product development and drug product regulatory sciences. The …

Abstract Formulation of nanocrystals is a robust approach which can improve delivery of
poorly water soluble drugs, a challenge pharmaceutical industry has been facing since long …

The complex process of oral drug absorption is influenced by a host of drug and formulation
properties as well as their interaction with the gastrointestinal environment in terms of drug …

OrBiTo is a new European project within the IMI programme in the area of oral
biopharmaceutics tools that includes world leading scientists from nine European …

Lipid-based formulations have been an attractive choice among novel drug delivery systems
for enhancing the solubility and bioavailability of poorly soluble drugs due to their ability to …

Enrofloxacin is a fluoroquinolone derivative used for treating urinary tract, respiratory and
skin infections in animals. However, low solubility and low bioavailability prevented it from …

The aim of this study was to prepare capsaicin-loaded micelle for oral administration and
pharmacokinetic studies in rats. The formulated capsaicin consisted of polyvinylpyrrolidone …

In this paper we analyse how the biopharmaceutics classification system (BCS) has been
used to date. A survey of the literature resulted in a compilation of 242 compounds for which …