Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species
ABSTRACT TAR DNA-binding protein (TDP-43, also known as TARDBP) is the major
pathological protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
pathological protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin
M Ogrodnik, H Salmonowicz, R Brown… - Proceedings of the …, 2014 - National Acad Sciences
Aging is associated with the accumulation of several types of damage: in particular, damage
to the proteome. Recent work points to a conserved replicative rejuvenation mechanism that …
to the proteome. Recent work points to a conserved replicative rejuvenation mechanism that …
Proteostasis
J Noack, G Brambilla Pisoni, M Molinari - Swiss medical weekly, 2014 - sonar.ch
The endoplasmic reticulum (ER) is an intracellular compartment dedicated to the synthesis
and maturation of secretory and membrane proteins, totalling about 30% of the total …
and maturation of secretory and membrane proteins, totalling about 30% of the total …
The nematode Caenorhabditis elegans: a versatile model for the study of proteotoxicity and aging
Y Volovik, FC Marques, E Cohen - Methods, 2014 - Elsevier
Toxicity arising from protein misfolding and aggregation (proteotoxicity) is tightly
mechanistically linked to the emergence of late-onset neurodegenerative disorders such as …
mechanistically linked to the emergence of late-onset neurodegenerative disorders such as …
Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis
K Cho, H Patil, E Senda, J Wang, H Yi, S Qiu… - Journal of Biological …, 2014 - ASBMB
The immunophilins, cyclophilins, catalyze peptidyl cis-trans prolyl-isomerization (PPIase), a
rate-limiting step in protein folding and a conformational switch in protein function …
rate-limiting step in protein folding and a conformational switch in protein function …
Studying the Molecular Determinants of Protein Oligomerization in Neurodegenerative Disorders by Bimolecular Fluorescence Complementation
F Herrera, S Gonçalves, JB dos Santos, TF Outeiro - Bio-nanoimaging, 2014 - Elsevier
The main feature of protein misfolding disorders is the presence of protein deposits in cells
and tissues as a consequence of aberrant protein–protein interactions. Neurodegenerative …
and tissues as a consequence of aberrant protein–protein interactions. Neurodegenerative …