eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei

ER Freire, AA Vashisht, AM Malvezzi, J Zuberek… - Rna, 2014 - rnajournal.cshlp.org
Members of the eIF4E mRNA cap-binding family are involved in translation and the
modulation of transcript availability in other systems as part of a three-component complex …

Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog

ER Freire, AM Malvezzi, AA Vashisht, J Zuberek… - Eukaryotic …, 2014 - Am Soc Microbiol
Trypanosomes lack the transcriptional control characteristic of the majority of eukaryotes that
is mediated by gene-specific promoters in a one-gene–one-promoter arrangement. Rather …

kdetrees: non-parametric estimation of phylogenetic tree distributions

G Weyenberg, PM Huggins, CL Schardl… - …, 2014 - academic.oup.com
Motivation: Although the majority of gene histories found in a clade of organisms are
expected to be generated by a common process (eg the coalescent process), it is well …

Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses

M Dacher, MA Morales, P Pescher… - Molecular …, 2014 - Wiley Online Library
L eishmania parasites cause important human morbidity and mortality. Essential L
eishmania genes escape genetic assessment by loss‐of‐function analyses due to lethal null …

Investigating the Chaperone Properties of a Novel Heat Shock Protein, Hsp70.c, from Trypanosoma brucei

A Burger, MH Ludewig, A Boshoff - Journal of Parasitology …, 2014 - Wiley Online Library
The neglected tropical disease, African Trypanosomiasis, is fatal and has a crippling impact
on economic development. Heat shock protein 70 (Hsp70) is an important molecular …

[HTML][HTML] An evolutionary ratchet leading to loss of elongation factors in eukaryotes

GC Atkinson, A Kuzmenko, I Chicherin… - BMC Evolutionary …, 2014 - Springer
Abstract Background The GTPase eEF1A is the eukaryotic factor responsible for the
essential, universal function of aminoacyl-tRNA delivery to the ribosome. Surprisingly …

The structure of Poz1-Tpz1 reveals a dimerization module in the fission yeast shelterin complex

C Stutz - 2014 - edoc.unibas.ch
Linear eukaryotic chromosomes are characterized by having distinct DNA ends. These
ends, designated telomeres, are threatened by continued shortening in replication …

Designing and Creating a Database for Effective Storage and Retrieval of Pediatric Drugs

J Somasunder - 2014 - cdr.lib.unc.edu
This paper discusses the creation of databases specially designed for pediatric drugs. There
are many medical drugs databases available currently for adults but there is no database for …

[PDF][PDF] Frederico Schmitt Kremer

TAC de Curso - ufpel.edu.br
Abstract KREMER, Frederico Schmitt. CestodaDB: developing a database for Cestoda
proteins. 2013. Final Year's Project (Bacharelado em Biotecnologia)–Curso de Bacharelado …