Highlights•IL-33 is a crucial activator of ILC2s in innate immunity and allergic
inflammation.•The gene encoding IL-33 is a major susceptibility locus for human asthma.•IL …

Unbiased genetic approaches, especially genome-wide association studies, have identified
novel genetic targets in the pathogenesis of asthma, but so far these targets account for only …

Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome …

Background In mice, group 2 innate lymphoid cells (ILC2s) likely mediate helminth immunity,
inflammation, and tissue repair and remodeling. However, the involvement of ILC2s in …

Interleukin-33 (IL-33) is an alarmin cytokine from the IL-1 family. IL-33 activates many
immune cell types expressing the interleukin 1 receptor-like 1 (IL1RL1) receptor ST2 …

Background Bronchial airway expression profiling has identified inflammatory
subphenotypes of asthma, but the invasiveness of this technique has limited its application …

Background Genome-wide association studies identified IL33 and IL-1 receptor–like 1
(IL1RL1)/IL18R1 as asthma susceptibility loci. IL33 and IL1RL1 constitute a single ligand …

Background Interleukin (IL)-33 is a new member of the IL-1 cytokine family and a promoter of
T helper type 2 (Th2) inflammation. IL-33 may be involved in the pathogenesis of atopic …

Platelets are enucleated cell fragments derived from megakaryocytes that play key roles in
hemostasis and in the pathogenesis of atherothrombosis and cancer. Platelet traits are …

Asthma was previously defined as an allergic Th2‐mediated inflammatory immune disorder.
Recently, this paradigm has been challenged because not all pathological changes …