Prodrug-based nanoparticulate drug delivery strategies for cancer therapy

C Luo, J Sun, B Sun, Z He - Trends in pharmacological sciences, 2014 - cell.com
Despite the rapid developments in nanotechnology and biomaterials, the efficient delivery of
chemotherapeutic agents is still challenging. Prodrug-based nanoassemblies have many …

Nanoemulsions in translational research—opportunities and challenges in targeted cancer therapy

S Ganta, M Talekar, A Singh, TP Coleman, MM Amiji - Aaps Pharmscitech, 2014 - Springer
Nanoemulsion dosage form serves as a vehicle for the delivery of active pharmaceutical
ingredients and has attracted great attention in drug delivery and pharmacotherapy. In …

Combination of small molecule prodrug and nanodrug delivery: amphiphilic drug–drug conjugate for cancer therapy

P Huang, D Wang, Y Su, W Huang… - Journal of the …, 2014 - ACS Publications
All drugs for cancer therapy face several transportation barriers on their tortuous journey to
the action sites. To overcome these barriers, an effective drug delivery system for cancer …

In Vivo and in Situ Tracking Cancer Chemotherapy by Highly Photostable NIR Fluorescent Theranostic Prodrug

X Wu, X Sun, Z Guo, J Tang, Y Shen… - Journal of the …, 2014 - ACS Publications
In vivo monitoring of the biodistribution and activation of prodrugs is urgently required. Near
infrared (NIR) fluorescence-active fluorophores with excellent photostability are preferable …

[HTML][HTML] Multifunctional enveloped mesoporous silica nanoparticles for subcellular co-delivery of drug and therapeutic peptide

GF Luo, WH Chen, Y Liu, Q Lei, RX Zhuo, XZ Zhang - Scientific reports, 2014 - nature.com
A multifunctional enveloped nanodevice based on mesoporous silica nanoparticle (MSN)
was delicately designed for subcellular co-delivery of drug and therapeutic peptide to tumor …

Enhancing the efficiency of gold nanoparticles treatment of cancer by increasing their rate of endocytosis and cell accumulation using rifampicin

MRK Ali, SR Panikkanvalappil… - Journal of the American …, 2014 - ACS Publications
To minimize the toxicity of gold nanoparticles (AuNPs) in cancer treatment, we have
developed a technique, which utilizes lesser amount of AuNPs while exhibiting increased …

Multi-drug delivery system based on alginate/calcium carbonate hybrid nanoparticles for combination chemotherapy

JL Wu, CQ Wang, RX Zhuo, SX Cheng - Colloids and Surfaces B …, 2014 - Elsevier
A facile strategy to prepare nano-sized drug carriers for co-delivery of multiple types of drugs
in combination chemotherapy was developed. Inorganic/organic hybrid alginate/CaCO 3 …

Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy

Y Li, R Liu, J Yang, G Ma, Z Zhang, X Zhang - Biomaterials, 2014 - Elsevier
The combination of chemotherapeutic drug camptothecin (CPT) and siPlk1 could prohibit
cancer development with combined effects. To ensure the two drugs could be …

Tunable temperature-responsive supramolecular hydrogels formed by prodrugs as a codelivery system

W Ha, J Yu, X Song, J Chen, Y Shi - ACS Applied Materials & …, 2014 - ACS Publications
Taking advantage of the strong hydrophobicity of the anticancer drug camptothecin (CPT),
the CPT molecule was conjugated to a class of low-molecular-weight (MW) poly (ethylene …

Folate-decorated and reduction-sensitive micelles assembled from amphiphilic polymer–camptothecin conjugates for intracellular drug delivery

C Liu, J Yuan, X Luo, M Chen, Z Chen… - Molecular …, 2014 - ACS Publications
It is one of the challenges for a wide clinical application of polymer micelles to address the
structure disintegration and premature drug release before reaching a pathological site. In …