Liposomes as carriers of hydrophilic small molecule drugs: strategies to enhance encapsulation and delivery
JO Eloy, MC de Souza, R Petrilli, JPA Barcellos… - Colloids and surfaces B …, 2014 - Elsevier
Although hydrophilic small molecule drugs are widely used in the clinic, their rapid
clearance, suboptimal biodistribution, low intracellular absorption and toxicity can limit their …
clearance, suboptimal biodistribution, low intracellular absorption and toxicity can limit their …
[HTML][HTML] Brain tumor-targeted drug delivery strategies
X Wei, X Chen, M Ying, W Lu - Acta pharmaceutica sinica B, 2014 - Elsevier
Despite the application of aggressive surgery, radiotherapy and chemotherapy in clinics,
brain tumors are still a difficult health challenge due to their fast development and poor …
brain tumors are still a difficult health challenge due to their fast development and poor …
Synthesis of Doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery
Targeted drug delivery is a promising alternative to overcome the limitations of classical
chemotherapy. In an ideal targeted drug delivery system carrier nanoparticles would be …
chemotherapy. In an ideal targeted drug delivery system carrier nanoparticles would be …
Beyond Warburg effect–dual metabolic nature of cancer cells
J Xie, H Wu, C Dai, Q Pan, Z Ding, D Hu, B Ji, Y Luo… - Scientific reports, 2014 - nature.com
Warburg effect is a dominant phenotype of most cancer cells. Here we show that this
phenotype depends on its environment. When cancer cells are under regular culture …
phenotype depends on its environment. When cancer cells are under regular culture …
Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel
The synthesis of polymer–drug conjugate (PDC) capable of convenient preparation and
controlled release of therapeutic agents is still an urgent requirement in drug delivery field …
controlled release of therapeutic agents is still an urgent requirement in drug delivery field …
The interaction of nanoparticles with plasma proteins and the consequent influence on nanoparticles behavior
Introduction: Plasma protein binding with nanoparticles (NPs) occurs immediately upon their
introduction into a physiological environment and is affected by the characteristics of NPs …
introduction into a physiological environment and is affected by the characteristics of NPs …
Crystal structure and its bearing towards an understanding of key biological functions of EpCAM
EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell
surface protein involved in homotypic cell–cell adhesion via intercellular oligomerization …
surface protein involved in homotypic cell–cell adhesion via intercellular oligomerization …
Polymeric micelles with stimuli-triggering systems for advanced cancer drug targeting
Since the 1990s, nanoscale drug carriers have played a pivotal role in cancer
chemotherapy, acting through passive drug delivery mechanisms and subsequent …
chemotherapy, acting through passive drug delivery mechanisms and subsequent …
Molecular imaging of the tumor microenvironment for precision medicine and theranostics
Morbidity and mortality from cancer and their associated conditions and treatments continue
to extract a heavy social and economic global burden despite the transformative advances …
to extract a heavy social and economic global burden despite the transformative advances …
Novel multiarm polyethylene glycol-dihydroartemisinin conjugates enhancing therapeutic efficacy in non-small-cell lung cancer
L Dai, L Wang, L Deng, J Liu, J Lei, D Li, J He - Scientific reports, 2014 - nature.com
The clinical application of dihydroartemisinin (DHA) has been hampered due to its poor
water-solubility. To overcome this hurdle, we devised a novel polymer-drug conjugate …
water-solubility. To overcome this hurdle, we devised a novel polymer-drug conjugate …