Amyloid beta: multiple mechanisms of toxicity and only some protective effects?

P Carrillo-Mora, R Luna… - Oxidative medicine and …, 2014 - Wiley Online Library
Amyloid beta (Aβ) is a peptide of 39–43 amino acids found in large amounts and forming
deposits in the brain tissue of patients with Alzheimer's disease (AD). For this reason, it has …

Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence

N Braidy, A Poljak, R Grant, T Jayasena, H Mansour… - Biogerontology, 2014 - Springer
Over the last decade, the importance of NAD+ has expanded beyond its role as an essential
cofactor for energy metabolism. NAD+ has emerged as a major signalling molecule that …

Neurodegenerative disorders: dysregulation of a carefully maintained balance?

C Swart, W Haylett, C Kinnear, G Johnson… - Experimental …, 2014 - Elsevier
The aggregation of misfolded proteins has long been regarded as a pathological event in
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and …

Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes

P Sarkar, I Zaja, M Bienengraeber… - American Journal …, 2014 - journals.physiology.org
Amyloid-β (Aβ) has long been implicated as a causative protein in Alzheimer's disease.
Cellular Aβ accumulation is toxic and causes mitochondrial dysfunction, which precedes …

Intromitochondrial IκB/NF-κB signaling pathway is involved in amyloid β peptide-induced mitochondrial dysfunction

C Shi, XM Zhu, J Wang, D Long - Journal of bioenergetics and …, 2014 - Springer
Mitochondrial dysfunction is a hallmark of amyloid β peptide (Aβ)-induced neuronal toxicity
in Alzheimer's disease (AD). However, the underlying mechanism (s) of Aβ-induced …

Mapping NAD+ Metabolism in the Brain of Ageing Wistar Rats: Potential Targets for Influencing Brain Senescence

P Sachdev, G Smythe, GJ Guillemin, T Chan-Ling… - 2014 - research.avondale.edu.au
Over the last decade, the importance of NAD? has expanded beyond its role as an essential
cofactor for energy metabolism. NAD? has emerged as a major signalling molecule that …

[HTML][HTML] Mitochondria in Cardiovascular Physiology and Disease: Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in …

P Sarkar, I Zaja, M Bienengraeber… - American Journal of …, 2014 - ncbi.nlm.nih.gov
Amyloid-β (Aβ) has long been implicated as a causative protein in Alzheimer's disease.
Cellular Aβ accumulation is toxic and causes mitochondrial dysfunction, which precedes …