Synthesis of cartilage by chondrocytes is an obligatory step for endochondral ossification.
Global deletion of the Runx2 gene results in complete failure of the ossification process, but …

Gene therapy using non-viral vectors that are safe and efficient in transfecting target cells is
an effective approach to overcome the shortcomings of protein delivery of growth factors …

Pluripotency of embryonic stem cells (ESCs) is maintained by transcriptional activities and
chromatin modifying complexes highly organized within the chromatin. Although much effort …

Cyclin A2 is a key player in the regulation of the cell cycle. Its degradation in mid-mitosis
relies on the ubiquitin-proteasome system (UPS). Using high-resolution microscopic …

Isoalantolactone, a sesquiterpene lactone, is the active component of Inula helenium
(Compositae). It has been reported that isoalantolactone has the capacity to inhibit tumor …

Proliferating Cell Nuclear Antigen (PCNA) is a key protein in DNA replication and repair. The
dynamics of replication and repair in live cells is usually studied introducing translational …

Cette thèse est composée de deux parties distinctes ayant comme thématique commune, la
synthèse d'hétérocycles via la catalyse organométallique. Nous nous sommes intéressés …

Cyclin A2 is a key actor in cell cycle regulation. Its degradation in mid-mitosis relies on the
ubiquitin-proteasome system (UPS). Using high resolution microscopic imaging, we find that …