14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

ML Bertolaccini, O Amengual, L Andreoli, T Atsumi… - Autoimmunity …, 2014 - Elsevier
Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use
of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in …

Antiphospholipid antibody testing and standardization

KMJ Devreese - International journal of laboratory hematology, 2014 - Wiley Online Library
The laboratory criteria that define patients with antiphospholipid syndrome (APS) include
lupus anticoagulant (LAC), anticardiolipin antibodies and anti‐β2 glycoprotein I antibodies …

A non–complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome

C Agostinis, P Durigutto, D Sblattero… - Blood, The Journal …, 2014 - ashpublications.org
A single-chain fragment variable (scFv) recognizing β2-glycoprotein 1 (β2GPI) from humans
and other species was isolated from a human phage display library and engineered to …

[图书][B] Recurrent pregnancy loss: causes, controversies, and treatment

HJA Carp - 2014 - books.google.com
Recurrent pregnancy loss presents a vexing clinical problem primarily for medical
professionals treating patients in reproductive medicine and in maternal-fetal medicine …

New tests to detect antiphospholipid antibodies: anti-domain I beta-2-glycoprotein-I antibodies

CB Chighizola, M Gerosa, PL Meroni - Current rheumatology reports, 2014 - Springer
Abstract Beta-2 glycoprotein I (β 2 GPI) is the main antigenic target for antiphospholipid
antibodies (aPL), the serological markers of antiphospholipid syndrome (APS). Domain I (DI) …

Revisiting the molecular mechanism of neurological manifestations in antiphospholipid syndrome: beyond vascular damage

M Carecchio, R Cantello, C Comi - Journal of Immunology …, 2014 - Wiley Online Library
Antiphospholipid syndrome (APS) is a multiorgan disease often affecting the central nervous
system (CNS). Typically, neurological manifestations of APS include thrombosis of cerebral …

The chequered history of the antiphospholipid syndrome

D Jayakody Arachchillage… - British journal of …, 2014 - Wiley Online Library
Consideration of the chronology of advances in medical knowledge can provide useful
insights into the pathogenesis, diagnosis and treatment of diseases. The antiphospholipid …

Laboratory methods to detect antiphospholipid antibodies

SA Krilis, B Giannakopoulos - Hematology 2014, the American …, 2014 - ashpublications.org
This chapter reviews several important themes pertaining to the antiphospholipid syndrome
(APS), including a description of the clinical features, a discussion of the main autoantigen …

Contribution of anti-β2glycoprotein I IgA antibodies to the diagnosis of anti-phospholipid syndrome: potential interest of target domains to discriminate thrombotic and …

L Despierres, A Beziane, G Kaplanski, B Granel… - …, 2014 - academic.oup.com
Objectives. Although the last international guidelines for aPL recommended determination of
IgA aCL and anti-β2glycoprotein I (aβ2GPI) antibodies for the evaluation of APS in the …

Thrombotic risk in the antiphospholipid syndrome

W Lim - Seminars in thrombosis and hemostasis, 2014 - thieme-connect.com
The antiphospholipid syndrome (APS) is characterized by venous or arterial thrombosis
and/or pregnancy morbidity in patients with persistent presence of antiphospholipid …