Neurotrophins in bladder function: what do we know and where do we go from here?

CD Cruz - Neurourology and urodynamics, 2014 - Wiley Online Library
Abstract Aims Neurotrophins (NTs) have attracted considerable attention in the urologic
community. The reason for this resides in the recognition of their ability to induce plastic …

Chapter 2: Pathophysiology of neurogenic detrusor overactivity and the symptom complex of “overactive bladder”

C Chapple - Neurourology and urodynamics, 2014 - Wiley Online Library
It is now clearly recognized that the function of the lower urinary tract represents a complex
interaction between the bladder and its outlet, acting under the control of the central nervous …

Increased severity of inflammation correlates with elevated expression of TRPV1 nerve fibers and nerve growth factor on interstitial cystitis/bladder pain syndrome

B Liu, F Yang, H Zhan, Z Feng, Z Zhang, W Li… - Urologia …, 2014 - karger.com
Objectives: Although evidence supports a role for inflammation in interstitial cystitis/bladder
pain syndrome (IC/BPS), the mechanism remains unknown. We determined whether …

Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male …

L Merrill, MA Vizzard - American Journal of Physiology …, 2014 - journals.physiology.org
Individuals with functional lower urinary tract disorders including interstitial cystitis
(IC)/bladder pain syndrome (BPS) and overactive bladder (OAB) often report symptom (eg …

[HTML][HTML] Neural mechanisms underlying lower urinary tract dysfunction

N Yoshimura, T Ogawa, M Miyazato… - Korean journal of …, 2014 - synapse.koreamed.org
This article summarizes anatomical, neurophysiological, and pharmacological studies in
humans and animals to provide insights into the neural circuitry and neurotransmitter …

Acupuncture versus solifenacin for treatment of overactive bladder and its correlation with urine nerve growth factor levels: a randomized, placebo-controlled clinical …

Y Aydoğmuş, M Sunay, H Arslan, A Aydın… - Urologia …, 2014 - karger.com
Objective: To determine whether acupuncture is effective as an overactive bladder (OAB)
treatment compared with solifenacin and placebo, and to investigate its relation with urine …

Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function

EJ Gonzalez, L Merrill… - American Journal of …, 2014 - journals.physiology.org
Urinary bladder dysfunction presents a major problem in the clinical management of patients
suffering from pathological conditions and neurological injuries or disorders. Currently, the …

Olmesartan ameliorates urinary dysfunction in the spontaneously hypertensive rat via recovering bladder blood flow and decreasing oxidative stress

S Shimizu, M Saito, H Oiwa, F Ohmasa… - Neurourology and …, 2014 - Wiley Online Library
Purpose As hypertension (HT) is one of the risk factors for lower urinary tract symptoms, we
investigated the effect of an angiotensin II type I receptor blocker, olmesartan, on bladder …

Neurotrophin signaling and visceral hypersensitivity

LY Qiao - Frontiers in biology, 2014 - Springer
Neurotrophin family are traditionally recognized for their nerve growth promoting function
and are recently identified as crucial factors in regulating neuronal activity in the central and …

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L Merrill, MA Vizzard - 2014 - journals.physiology.org
1 R-00008-2014R2 Intravesical TRPV4 blockade reduces repeated variate stress (RVS)-induced
bladder dysfunction by increasing bla Page 1 1 R-00008-2014R2 1 Intravesical TRPV4 …