Kinins are generated within inflammatory tissue microenvironments, where they exert
diverse functions, including cell proliferation, leukocyte activation, cell migration, endothelial …

Endogenous kinins are important vasoactive peptides whose effects are mediated by two G-
Protein-coupled receptors (R), named B2R (constitutive) and B1R (inducible). They are …

Diabetic retinopathy (DR) is a major microvascular complication associated with type 1 and
type 2 diabetes mellitus, which can lead to visual impairment and blindness. Current …

The kallikrein-kinin and renin-angiotensin systems interact at multiple levels. In the present
study, we tested the hypothesis that the B1 kinin receptor (B1R) contributes to vascular …

The efficacy of the ACE (angiotensin-converting enzyme) inhibitor perindopril in coronary
artery disease [EUROPA (European trial on reduction of cardiac events with perindopril in …

The following summarises the plenary lectures of the 'Bradykinin Symposium 2012'held on
23-24 August 2012 at Charité-Universitätsmedizin Berlin, Germany. The summary begins …

2011-11-09 Assigned to GRUENENTHAL GMBH reassignment GRUENENTHAL GMBH
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

Cisplatin is a chemotherapeutic agent that causes severe renal dysfunction. The kinin B1
receptor has been associated with the migration of immune cells to injured tissue as well as …

Genetic manipulation of the kallikrein-kinin system (KKS) in mice, with either gain or loss of
function, and study of human genetic variability in KKS components which has been well …

Noxious stimuli and non-noxious mechanical stimuli elicit itch (alloknesis) instead of pain on
skin lesions of patients with atopic dermatitis. We previously found that bradykinin evokes an …