Programming of neural cells by (endo) cannabinoids: from physiological rules to emerging therapies

M Maccarrone, M Guzmán, K Mackie… - Nature Reviews …, 2014 - nature.com
Among the many signalling lipids, endocannabinoids are increasingly recognized for their
important roles in neuronal and glial development. Recent experimental evidence suggests …

Aging in the olfactory system

AS Mobley, DJ Rodriguez-Gil, F Imamura… - Trends in …, 2014 - cell.com
With advancing age, the ability of humans to detect and discriminate odors declines. In light
of the rapid progress in analyzing molecular and structural correlates of developing and …

Miswiring the brain: Δ9‐tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin‐2 degradation pathway

G Tortoriello, CV Morris, A Alpar, J Fuzik… - The EMBO …, 2014 - embopress.org
Children exposed in utero to cannabis present permanent neurobehavioral and cognitive
impairments. Psychoactive constituents from Cannabis spp., particularly Δ9 …

Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth

AB Roland, A Ricobaraza, D Carrel, BM Jordan, F Rico… - Elife, 2014 - elifesciences.org
Endocannabinoids are recently recognized regulators of brain development, but molecular
effectors downstream of type-1 cannabinoid receptor (CB1R)-activation remain incompletely …

The cannabinoid CB2 receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis

HK Avraham, S Jiang, Y Fu… - British journal of …, 2014 - Wiley Online Library
Background and Purpose HIV‐1 glycoprotein G p120 induces apoptosis in rodent and
human neurons in vitro and in vivo. HIV‐1/G p120 is involved in the pathogenesis of HIV …

Functions of the CB1 and CB2 Receptors in Neuroprotection at the Level of the Blood–Brain Barrier

E Vendel, ECM de Lange - Neuromolecular medicine, 2014 - Springer
The cannabinoid (CB) receptors are the main targets of the cannabinoids, which include
plant cannabinoids, endocannabinoids and synthetic cannabinoids. Over the last few years …

Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of …

E Blanco-Calvo, P Rivera, S Arrabal… - Frontiers in integrative …, 2014 - frontiersin.org
Addiction to major drugs of abuse, such as cocaine, has recently been linked to alterations
in adult neurogenesis in the hippocampus. The endogenous cannabinoid system modulates …

Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting

F Fezza, MC Marrone, R Avvisati… - Molecular and Cellular …, 2014 - Elsevier
There is clear evidence on the neuroprotective role of the endocannabinoid (eCB) signaling
cascade in various models of epilepsy. In particular, increased levels of eCBs protect …

Extracellular signals controlling neuroblast migration in the postnatal brain

G Lalli - Cellular and Molecular Control of Neuronal Migration, 2014 - Springer
The most prominent example of long-distance migration in the postnatal brain is the rostral
migratory stream (RMS) formed by neuroblasts originating in the subventricular zone (SVZ) …

Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?

S Xapelli, F Agasse, S Grade, L Bernardino… - Frontiers in Cellular …, 2014 - frontiersin.org
Neural stem cells (NSCs) from the subventricular zone (SVZ) have been indicated as a
source of new oligodendrocytes to use in regenerative medicine for myelin pathologies …