The hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and
hepatocellular carcinoma worldwide. A significant portion of the morbidity and mortality …

People who inject drugs (PWID) represent the core of the hepatitis C virus (HCV) epidemic
in many countries and HCV-related disease burden continues to rise. There are compelling …

Background Interferon-containing regimens for the treatment of hepatitis C virus (HCV)
infection are associated with increased toxic effects in patients who also have cirrhosis. We …

Background and aims MicroRNA-122 (miR-122) is an important host factor for hepatitis C
virus (HCV) and promotes HCV RNA accumulation. Decreased intra-hepatic levels of miR …

Aims To determine the relationship between methadone maintenance therapy (MMT) and
hepatitis C (HCV) seroconversion among illicit drug users. Design A generalized estimating …

Abstract Cholesterol 25-hydroxylase (CH25H) as an interferon-stimulated gene (ISG) has
recently been shown to exert broad antiviral activity through the production of 25 …

Abstract Background & Aims Despite advances in HCV treatment, recent data on treatment
uptake is sparse. HCV treatment uptake and associated factors were evaluated in a …

HCV infections are a major global health burden. After the identification of the virus in 1989,
insights into viral replication and drug development have long been hampered by the lack of …

Hepatitis C virus (HCV) assembles its replication complex on cytosolic membrane vesicles
often clustered in a membranous web (MW). During infection, HCV NS5A protein activates …

Background & Aim Interferon (IFN) negatively impacts patients' well-being and patient-
reported outcomes (PROs). Our aim was to assess PROs during treatment with an IFN-free …