Aquaporins in the eye: expression, function, and roles in ocular disease

KL Schey, Z Wang, JL Wenke, Y Qi - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Background All thirteen known mammalian aquaporins have been detected in the eye.
Moreover, aquaporins have been identified as playing essential roles in ocular functions …

The aquaporin zero puzzle

JE Hall, RT Mathias - Biophysical Journal, 2014 - cell.com
Aquaporin zero (AQP0) is a water channel expressed almost exclusively in fiber cells of the
lens of the eye. There is a long-standing hypothesis that AQP0 functions as both a water …

Aquaporin-0 targets interlocking domains to control the integrity and transparency of the eye lens

WK Lo, SK Biswas, L Brako, A Shiels… - … & visual science, 2014 - iovs.arvojournals.org
Purpose.: Lens fiber cell membranes contain aquaporin-0 (AQP0), which constitutes
approximately 50% of the total fiber cell membrane proteins and has a dual function as a …

Aquaporin 0 plays a pivotal role in refractive index gradient development in mammalian eye lens to prevent spherical aberration

SS Kumari, K Varadaraj - Biochemical and biophysical research …, 2014 - Elsevier
Abstract Aquaporin 0 (AQP0) is a transmembrane channel that constitutes∼ 45% of the total
membrane protein of the fiber cells in mammalian lens. It is critical for lens transparency and …

Intact and N-or C-terminal end truncated AQP0 function as open water channels and cell-to-cell adhesion proteins: end truncation could be a prelude for adjusting the …

SS Kumari, K Varadaraj - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
Background Investigate the impact of natural N-or C-terminal post-translational truncations
of lens mature fiber cell Aquaporin 0 (AQP0) on water permeability (Pw) and cell-to-cell …

Expression of the HSF4 DNA binding domain-EGFP hybrid gene recreates early childhood lamellar cataract in transgenic mice

RK Gangalum, Z Jing, AM Bhat, J Lee… - … & Visual Science, 2014 - iovs.arvojournals.org
Purpose: The clinical management of cataracts in infancy involves surgical removal of the
lens to ensure transmission of light to the retina, which is essential for normal neural …

[图书][B] Functional characterization of small Maf transcription factors MafG and MafK in mammalian lens homeostasis

SA Agrawal - 2014 - search.proquest.com
FIRST LINE OF TITLE Page 1 FUNCTIONAL CHARACTERIZATION OF SMALL MAF
TRANSCRIPTION FACTORS MAFG AND MAFK IN MAMMALIAN LENS HOMEOSTASIS by …