CRISPR-Cas9 knockin mice for genome editing and cancer modeling
CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic
elements. To broadly enable the application of Cas9 in vivo, we established a Cre …
elements. To broadly enable the application of Cas9 in vivo, we established a Cre …
Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation
Cardiovascular diseases such as atherosclerosis are one of the leading causes of morbidity
and mortality worldwide. The clinical manifestations of atherosclerosis, which include heart …
and mortality worldwide. The clinical manifestations of atherosclerosis, which include heart …
Small RNA combination therapy for lung cancer
MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their
effective delivery to most solid tumors has been difficult. Here, we show that a new lung …
effective delivery to most solid tumors has been difficult. Here, we show that a new lung …
Nanotechnology for in vivo targeted siRNA delivery
Small interfering RNAs (siRNAs) can specifically inhibit gene expression. As a result, they
have tremendous scientific and clinical potential. However, the use of these molecules in …
have tremendous scientific and clinical potential. However, the use of these molecules in …
Ionizable amphiphilic dendrimer‐based nanomaterials with alkyl‐chain‐substituted amines for tunable siRNA delivery to the liver endothelium in vivo
A library of dendrimers was synthesized and optimized for targeted small interfering RNA
(siRNA) delivery to different cell subpopulations within the liver. Using a combinatorial …
(siRNA) delivery to different cell subpopulations within the liver. Using a combinatorial …
Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles
Efficient delivery of short interfering RNAs reflects a prerequisite for the development of RNA
interference therapeutics. Here, we describe highly specific nanoparticles, based on near …
interference therapeutics. Here, we describe highly specific nanoparticles, based on near …
Cell-specific therapy on target
DTW Clarke, NAJ McMillan - Nature Nanotechnology, 2014 - nature.com
Cell-specific therapy on target | Nature Nanotechnology Skip to main content Thank you for
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visiting nature.com. You are using a browser version with limited support for CSS. To obtain …
Convergence of nanotechnology and cancer prevention: are we there yet?
DG Menter, SL Patterson, CD Logsdon, S Kopetz… - Cancer Prevention …, 2014 - AACR
Nanotechnology is emerging as a promising modality for cancer treatment; however, in the
realm of cancer prevention, its full utility has yet to be determined. Here, we discuss the …
realm of cancer prevention, its full utility has yet to be determined. Here, we discuss the …
Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
F Zhang, M HEDENREICH, L SWIECH - 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52105123&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
52105123&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
F Zhang, P Hsu, C Lin, RAN Fei, L SWIECH - 2014 - Google Patents
WO2014204725A1 - Optimized crispr-cas double nickase systems, methods and
compositions for sequence manipulation - Google Patents WO2014204725A1 - Optimized …
compositions for sequence manipulation - Google Patents WO2014204725A1 - Optimized …