Molecular basis of pharmacological therapy in Cushing's disease

D Ferone, C Pivonello, G Vitale, MC Zatelli, A Colao… - Endocrine, 2014 - Springer
Cushing's disease (CD) is a severe endocrine condition caused by an adrenocorticotropin
(ACTH)-producing pituitary adenoma that chronically stimulates adrenocortical cortisol …

Fine‐tuning somatostatin receptor signalling by agonist‐selective phosphorylation and dephosphorylation: IUPHAR Review 5

S Schulz, A Lehmann, A Kliewer… - British journal of …, 2014 - Wiley Online Library
The biological actions of somatostatin are mediated by a family of five GPCRs, named sst1
to sst5. Somatostatin receptors exhibit equally high‐binding affinities to their natural ligand …