Pseudomonas aeruginosa Biofilms in Disease

LR Mulcahy, VM Isabella, K Lewis - Microbial ecology, 2014 - Springer
Pseudomonas aeruginosa is a ubiquitous organism that is the focus of intense research
because of its prominent role in disease. Due to its relatively large genome and flexible …

Mixed‐species biofilm compromises wound healing by disrupting epidermal barrier function

S Roy, H Elgharably, M Sinha, K Ganesh… - The Journal of …, 2014 - Wiley Online Library
In chronic wounds, biofilm infects host tissue for extended periods of time. This work
establishes the first chronic preclinical model of wound biofilm infection aimed at addressing …

A clinical algorithm for wound biofilm identification

DG Metcalf, PG Bowler, J Hurlow - Journal of wound care, 2014 - magonlinelibrary.com
Recognition of the existence of biofilm in chronic wounds is increasing among wound care
practitioners, and a growing body of evidence indicates that biofilm contributes significantly …

Biofilm-infected pressure ulcers: current knowledge and emerging treatment strategies

L Suleman, SL Percival - Biofilm-based Healthcare-associated Infections …, 2014 - Springer
Pressure ulcers, otherwise known as decubitus ulcers, are a type of chronic wound that are
commonly seen in the healthcare environment, particularly in the elderly. The loss of barrier …

An investigation of in vivo wound healing activity of biologically synthesized silver nanoparticles

A Kaler, AK Mittal, M Katariya, H Harde… - Journal of nanoparticle …, 2014 - Springer
Therapeutic use of nano-silver is claimed to have reduced side effects and enhanced
curative activity as compared to its ionic counterpart (silver ions). The present work aims to …

Impact of a novel, antimicrobial dressing on in vivo, Pseudomonas aeruginosa wound biofilm: Quantitative comparative analysis using a rabbit ear model

AK Seth, A Zhong, KT Nguyen, SJ Hong… - Wound Repair and …, 2014 - Wiley Online Library
The importance of bacterial biofilms to chronic wound pathogenesis is well established.
Different treatment modalities, including topical dressings, have yet to show consistent …

Activity of Imipenem against Klebsiella pneumoniae Biofilms In Vitro and In Vivo

P Chen, AK Seth, JJ Abercrombie… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Encapsulated Klebsiella pneumoniae has emerged as one of the most clinically relevant
and more frequently encountered opportunistic pathogens in combat wounds as the result of …

[HTML][HTML] Dermal wound transcriptomic responses to Infection with Pseudomonas aeruginosa versus Klebsiella pneumoniae in a rabbit ear wound model

KP Leung, P D'Arpa, AK Seth, MR Geringer, M Jett… - BMC Clinical …, 2014 - Springer
Background Bacterial infections of wounds impair healing and worsen scarring. We
hypothesized that transcriptome analysis of wounds infected with Klebsiella pneumoniae …

Evaluating the effects of subclinical, cyclic ischemia-reperfusion injury on wound healing using a novel device in the rabbit ear

JP Steinberg, AN Gurjala, S Jia, SJ Hong… - Annals of plastic …, 2014 - journals.lww.com
Objective This study aimed to evaluate the effect of cyclic ischemia-reperfusion (IR) injury on
wound healing using a novel rabbit ear model. Materials and Methods A lightweight clamp …

Avaliação da terapia fágica em biofilmes bacterianos presentes em feridas crónicas

MSM Andrade - 2014 - search.proquest.com
As feridas crónicas são lesões na pele que apresentam grande dificuldade de cicatrização,
persistindo por longos períodos de tempo e que causam dor, stresse emocional e físico …