The development of colorectal cancer (CRC) can be influenced by genetic factors in both
familial cases and sporadic cases. Familial CRC has been associated with genetic changes …

Carriers of a germline mutation in one of the DNA mismatch repair (MMR) genes have a
high risk of developing numerous different cancers, predominantly colorectal cancer and …

Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients
With Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for …

Lynch syndrome (LS) is caused by germline mutations in mismatch repair (MMR) genes,
resulting in microsatellite‐unstable tumours. Approximately 35% of suspected LS (sLS) …

Lynch syndrome, familial adenomatous polyposis, and Mut Y homolog (MYH)-associated
polyposis are three major known types of inherited colorectal cancer, which accounts for up …

Introduction The distribution of histopathological features of invasive breast tumors in
BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known …

DNA replication errors that persist as mismatch mutations make up the molecular fingerprint
of mismatch repair (MMR)-deficient tumors and convey them with resistance to standard …

Background and aims Lynch syndrome (LS) patients have DNA mismatch repair deficiency
and up to 80% lifetime risk of colorectal cancer (CRC). Screening of mutation carriers …

Introduction Colorectal cancer is a heterogeneous tumor type with regard to molecular
pathogenesis and genetic instability. The majority of colorectal cancers display …

Abstract Recently BRAF V600E mutant–specific antibody (clone VE1) became available to
immunohistochemically pinpoint the occurrence of these BRAF-mutant proteins in different …