Cardiomyopathies (ie, diseases of the heart muscle) are major causes of morbidity and
mortality. A significant percentage of patients with cardiomyopathies have genetic-based …

Dilated cardiomyopathy is a disease of the myocardium characterized by left ventricular
dilatation and/or dysfunction, affecting both adult and pediatric populations. Almost half of …

Depressed sarcoplasmic reticulum (SR) calcium cycling, reflecting impaired SR Ca-transport
and Ca-release, is a key and universal characteristic of human and experimental heart …

Background Eosinophilic esophagitis (EoE) is a chronic antigen-mediated disease
characterized by esophageal eosinophilia, remodeling, and fibrosis. TGF-β1 is a central …

Introduction: Cardiovascular gene therapy is the third most popular application for gene
therapy, representing 8.4% of all gene therapy trials as reported in 2012 estimates. Gene …

MicroRNAs (miRNAs) have emerged as potent modulators of mammalian gene expression,
thereby broadening the spectrum of molecular mechanisms orchestrating human …

Cardiomyopathies are a heterogeneous group of heart muscle diseases associated with
heart failure, arrhythmias, and death. Genetic variation has a critical role in the pathogenesis …

Background Cardiovascular disease (CVD) is the leading cause of death in the developed
world. Human genetic studies, including genome-wide sequencing and SNP-array …

Myocardial fibrosis can lead to heart failure and act as a substrate for cardiac arrhythmias. In
dilated cardiomyopathy diffuse interstitial reactive fibrosis can be observed, whereas …

Arrhythmogenic cardiomyopathy (AC) is a primary myocardial disorder characterized by a
high incidence of ventricular arrhythmias often preceding the onset of ventricular remodeling …