The eukaryotic genome is organized in the three-dimensional nuclear space in a specific
manner that is both a cause and a consequence of its function. This organization is partly …

It can be convenient to think of the genome as simply a string of nucleotides, the linear order
of which encodes an organism's genetic blueprint. However, the genome does not exist as a …

The pluripotent state of embryonic stem cells (ESCs) is produced by active transcription of
genes that control cell identity and repression of genes encoding lineage-specifying …

The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-
range chromatin loops with the MYC oncogene, but how chromatin looping at the MYC locus …

Long-range regulatory interactions play an important role in shaping gene-expression
programs. However, the genomic features that organize these activities are still poorly …

Increasing evidence suggests that interactions between regulatory genomic elements play
an important role in regulating gene expression. We generated a genome-wide interaction …

Background Chromosome conformation capture studies suggest that eukaryotic genomes
are organized into structures called topologically associating domains. The borders of these …

The precise, temporal order of gene expression during development is critical to ensure
proper lineage commitment, cell fate determination, and ultimately, organogenesis …

Enhancer mapping has been greatly facilitated by various genomic marks associated with it.
However, little is available in our toolbox to link enhancers with their target promoters …

The main oncogenic driver in T-lymphoblastic leukemia is NOTCH1, which activates genes
by forming chromatin-associated Notch transcription complexes. Gamma-secretase-inhibitor …