The microbial mechanisms and key metabolites that shape the composition of the human
gut microbiota are largely unknown, impeding efforts to manipulate dysbiotic microbial …

The inherent drug susceptibility of microorganisms is determined by multiple factors,
including growth state, the rate of drug diffusion into and out of the cell, and the intrinsic …

Genome-Wide Association Studies (GWAS), whole genome sequencing, and high-
throughput omics techniques have generated vast amounts of genotypic and molecular …

ABC transporters comprise a large, diverse, and ubiquitous superfamily of membrane active
transporters. Their core architecture is a dimer of dimers, comprising two transmembrane …

Due to their lack of toxicity to mammalian cells and good serum stability, proline-rich
antimicrobial peptides (PR-AMPs) have been proposed as promising candidates for the …

Leprosy is caused by infection with Mycobacterium leprae and is classified clinically into
paucibacillary (PB) or multibacillary (MB) subtypes based on the number of skin lesions and …

In the 15 years since the publication of the genome sequence of Mycobacterium
tuberculosis, analysis of transcriptional regulation has provided a dominant framework for …

Bedaquiline was the first novel antitubercular to be approved by the FDA in over 4 decades
(1); delamanid is likely to follow soon (2), and there are a number of others in the pipeline …

There are many chemotherapeutic interventions available for tuberculosis (TB) and are in
use for more than five decades, but still there is an urgent need for novel drugs against new …

Broad-host pathogens have adapted a lifestyle that enables them to survive and replicate in
different environments. Mycobacterium marinum, a close relative of Mycobacterium …