Derivatization for liquid chromatography-mass spectrometry

BL Qi, P Liu, QY Wang, WJ Cai, BF Yuan… - TrAC Trends in Analytical …, 2014 - Elsevier
Liquid chromatography-mass spectrometry (LC-MS) is one of the most prominent analytical
techniques, due to its inherent selectivity and sensitivity. In LC-MS, chemical derivatizations …

[HTML][HTML] Interactions between endocrine and circadian systems

AH Tsang, JL Barclay, H Oster - Journal of molecular …, 2014 - jme.bioscientifica.com
Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …

Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia

A Chapagain, PW Caton, J Kieswich… - Proceedings of the …, 2014 - National Acad Sciences
Insulin resistance and associated metabolic sequelae are common in chronic kidney
disease (CKD) and are positively and independently associated with increased …

Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning

RA Sarabdjitsingh, M Zhou, JLW Yau, SP Webster… - …, 2014 - Elsevier
Abstract 11β-Hydroxysteroid dehydrogenase type 1 (11β− HSD1) catalyzes intracellular
regeneration of corticosterone and cortisol, thereby enhancing glucocorticoid action …

Metabolites in vertebrate Hedgehog signaling

H Roberg-Larsen, MF Strand, S Krauss… - … and biophysical research …, 2014 - Elsevier
The Hedgehog (HH) signaling pathway is critical in embryonic development, stem cell
biology, tissue homeostasis, chemoattraction and synapse formation. Irregular HH signaling …