Casein kinase: the triple meaning of a misnomer
The term 'casein kinase'has been widely used for decades to denote protein kinases sharing
the ability to readily phosphorylate casein in vitro. These fall into three main classes: two of …
the ability to readily phosphorylate casein in vitro. These fall into three main classes: two of …
[HTML][HTML] Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN …
AM Gomes, MVD Soares, P Ribeiro, J Caldas… - …, 2014 - ncbi.nlm.nih.gov
Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring
a better characterization of the molecular determinants underlying disease progression and …
a better characterization of the molecular determinants underlying disease progression and …
Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling
F Buontempo, E Orsini, LR Martins, I Antunes, A Lonetti… - Leukemia, 2014 - nature.com
Constitutively active casein kinase 2 (CK2) signaling is a common feature of T-cell acute
lymphoblastic leukemia (T-ALL). CK2 phosphorylates PTEN (phosphatase and tensin …
lymphoblastic leukemia (T-ALL). CK2 phosphorylates PTEN (phosphatase and tensin …
A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene …
P Foka, A Dimitriadis, E Kyratzopoulou… - Cellular and molecular …, 2014 - Springer
Hepatitis C virus (HCV) infection is associated with hepatic iron overload and elevated
serum iron that correlate to poor antiviral responses. Hepcidin (HAMP), a 25-aa cysteine-rich …
serum iron that correlate to poor antiviral responses. Hepcidin (HAMP), a 25-aa cysteine-rich …
[HTML][HTML] CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells
S Zhang, YL Yang, Y Wang, B You, Y Dai… - Journal of Experimental …, 2014 - Springer
Abstract Background The Hedgehog (Hh) signaling pathway has been implicated in stem
cell maintenance and its activation is aberrant in several types of cancer including …
cell maintenance and its activation is aberrant in several types of cancer including …
Bone marrow stromal cell-fueled multiple myeloma growth and osteoclastogenesis are sustained by protein kinase CK2
5 Barbui T, Thiele J, Carobbio A, Guglielmelli P, Rambaldi A, Vannucchi A et al.
Discriminating between essential thrombocythemia and masked polycythemia vera in JAK2 …
Discriminating between essential thrombocythemia and masked polycythemia vera in JAK2 …
[HTML][HTML] Tenfibgen-DMAT nanocapsule delivers CK2 inhibitor DMAT to prostate cancer xenograft tumors causing inhibition of cell proliferation
CK2 is a master regulator protein kinase which demonstrates heightened expression in
diverse cancer types and is considered a promising target for therapy. Given its ubiquitous …
diverse cancer types and is considered a promising target for therapy. Given its ubiquitous …
Structure‐Based Design of Protein Kinase Inhibitors
Protein kinases are important drug design targets. This chapter overviews structure‐based
design of hinge binding heterocycles and functionalities that are utilized in the design of …
design of hinge binding heterocycles and functionalities that are utilized in the design of …
Protein kinase CK2: a new target to overcome imatinib-resistance in chronic myeloid leukemia cells
V Salizzato - 2014 - research.unipd.it
Chronic myeloid leukemia (CML), a malignant myeloproliferative disorder of hematopoietic
system, is driven by the chromosomal translocation [t (9; 22)(q34; q11)], yielding the …
system, is driven by the chromosomal translocation [t (9; 22)(q34; q11)], yielding the …