A critical review of which children with acute myeloid leukaemia need stem cell procedures

H Hasle - British journal of haematology, 2014 - Wiley Online Library
The last decades have seen parallel improvements in chemotherapy‐based and
haematopoietic stem cell transplantation (HSCT) regimens for acute myeloid leukaemia …

NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report

F Ostronoff, M Othus, RB Gerbing… - Blood, The Journal …, 2014 - ashpublications.org
NUP98/NSD1 has recently been reported in association with poor outcome in acute myeloid
leukemia (AML). Previous studies also observed a high overlap between NUP98/NSD1 and …

[HTML][HTML] t (6; 9)(p22; q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients

JD Sandahl, EA Coenen, E Forestier, J Harbott… - …, 2014 - ncbi.nlm.nih.gov
Acute myeloid leukemia with t (6; 9)(p22; q34) is listed as a distinct entity in the 2008 World
Health Organization classification, but little is known about the clinical implications of t (6; 9) …

Overview of therapy and strategies for optimizing outcomes in de novo pediatric acute myeloid leukemia

K Faulk, L Gore, T Cooper - Pediatric Drugs, 2014 - Springer
Although acute myelogenous leukemia (AML) accounts for< 20% of leukemia in children, it
is responsible for over half of all pediatric leukemia deaths. Improvement in event-free …

Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3‐ITD status: a report from the Children's …

K Tarlock, TA Alonzo, PP Moraleda… - British journal of …, 2014 - Wiley Online Library
Acute myeloid leukaemia (AML) with t (6; 9)(p23; q34) is a rare subtype associated with
FLT3‐internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of …

[HTML][HTML] Prognostic significance of NPM1 mutations in acute myeloid leukemia: A meta-analysis

Y Liu, P He, F Liu, L Shi, H Zhu… - Molecular and …, 2014 - spandidos-publications.com
Nucleophosmin 1 (NPM1) mutations have been identified in a substantial number of patients
with acute myeloid leukemia (AML). Favorable outcomes in AML cases with NPM1 …

Hyperdiploidy with 49–65 chromosomes represents a heterogeneous cytogenetic subgroup of acute myeloid leukemia with differential outcome

L Chilton, RK Hills, CJ Harrison, AK Burnett… - Leukemia, 2014 - nature.com
Chromosome gain is frequent in acute myeloid leukemia (AML) and is counted alongside
structural abnormalities when determining karyotype complexity. However, there are few …

Outcome of children with relapsed acute myeloid leukemia following initial therapy under the AML99 protocol

H Nakayama, K Tabuchi, A Tawa, I Tsukimoto… - International journal of …, 2014 - Springer
The outcomes of children with relapsed acute myeloid leukemia (AML) are known to be
poor, but remain obscure. We retrospectively analyzed 71 patients who had relapsed …

Comparable survival for pediatric acute myeloid leukemia with poor‐risk cytogenetics following chemotherapy, matched related donor, or unrelated donor …

MJ Kelly, JT Horan, TA Alonzo, M Eapen… - Pediatric blood & …, 2014 - Wiley Online Library
Background We sought to better define the role of hematopoietic cell transplantation (HCT)
in first remission (CR1) for high‐risk pediatric acute myeloid leukemia (AML). Procedures …

Ploidy and clinical characteristics of childhood acute myeloid leukemia: A NOPHO‐AML study

JD Sandahl, E Kjeldsen, J Abrahamsson… - Genes …, 2014 - Wiley Online Library
We report the first large series (n= 596) of pediatric acute myeloid leukemia (AML) focusing
on modal numbers (MN) from the population‐based NOPHO‐AML trials. Abnormal …