The heart is highly sensitive to the aging process. In the elderly, the heart tends to become
hypertrophic and fibrotic. Stiffness increases with ensuing systolic and diastolic dysfunction …

Ischemia-reperfusion (IR) injury is significantly worse in aged hearts, but the underlying
mechanisms are poorly understood. Age-related damage to mitochondria may be a critical …

Summary In the United States, life expectancy has markedly increased during the past
century, and population ageing is expected to double within the next 25 years. The process …

Calorie restriction (CR) has been shown to increase longevity and mitigate age‑associated
diseases in various organisms. Numerous studies have identified that sirtuin 1 (SIRT1) is …

Doxorubicin (Dox) is one of the most effective chemotherapeutic agents used in the
treatment of several types of cancer. However the use is limited by cardiotoxicity. Despite …

Thyroid hormones (TH) are believed to participate in adaptation of the heart to dietary caloric
restriction (CR). The effect of CR on cardiac thyroid hormone receptors α and β (TRα and TR …

短篇综述自噬在心肌衰老中作用的研究进M Page 1 2014年8Л 第34卷第8期 基础医学与临床
Basic&clinicalmedicine August2014 Vol.34 No.8 !"#$:20131012 %&#$:20131223 '()*:国家 …

Podwzgórzowy czynnościowy brak miesiączki (z ang. functional hypothalamic amenorrhea–
FHA) jest odwracalnym zaburzeniem układu wydzielania wewnętrznego, które …

Autophagy plays an important role in sustaining the survival of cardiomyocytes during aging
process. Regulating autophagy will contribute to the elimination of impaired mitochondria …

Ischemia-reperfusion (IR) injury is significantly worse in aged hearts, but the underlying
mechanisms are poorly understood. Age-related damage to mitochondria may be a critical …