Mechanisms regulating endothelial permeability
The endothelial monolayer partitioning underlying tissue from blood components in the
vessel wall maintains tissue fluid balance and host defense through dynamically opening …
vessel wall maintains tissue fluid balance and host defense through dynamically opening …
[HTML][HTML] The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux
N Joseph, B Reicher, M Barda-Saad - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
During T cell activation, the engagement of a T cell with an antigen-presenting cell (APC)
results in rapid cytoskeletal rearrangements and a dramatic increase of intracellular calcium …
results in rapid cytoskeletal rearrangements and a dramatic increase of intracellular calcium …
Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA
The endoplasmic reticulum (ER) and mitochondria accumulate Ca2+ within their lumens to
regulate numerous cell functions. However, determining the dynamics of intraorganellar …
regulate numerous cell functions. However, determining the dynamics of intraorganellar …
The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
S Bertin, Y Aoki-Nonaka, PR De Jong, LL Nohara… - Nature …, 2014 - nature.com
Abstract TRPV1 is a Ca2+-permeable channel studied mostly as a pain receptor in sensory
neurons. However, its role in other cell types is poorly understood. Here we found that …
neurons. However, its role in other cell types is poorly understood. Here we found that …
Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis
V Nesin, G Wiley, M Kousi, EC Ong… - Proceedings of the …, 2014 - National Acad Sciences
Signaling through the store-operated Ca2+ release-activated Ca2+ (CRAC) channel
regulates critical cellular functions, including gene expression, cell growth and …
regulates critical cellular functions, including gene expression, cell growth and …
Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer
ORAI family channels have emerged as important players in malignant transformation, yet
the way in which they reprogram cancer cells remains elusive. Here we show that the …
the way in which they reprogram cancer cells remains elusive. Here we show that the …
STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion
J Sun, F Lu, H He, J Shen, J Messina, R Mathew… - Journal of Cell …, 2014 - rupress.org
Ca2+ signaling has been increasingly implicated in cancer invasion and metastasis, and
yet, the underlying mechanisms remained largely unknown. In this paper, we report that …
yet, the underlying mechanisms remained largely unknown. In this paper, we report that …
Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site
The ER membrane-spanning STIM1 protein is a finely-tuned sensor of ER luminal Ca 2+.
Small changes in ER Ca 2+ induce STIM1 to undergo an intricate self-triggering process …
Small changes in ER Ca 2+ induce STIM1 to undergo an intricate self-triggering process …
Stable expression and function of the inositol 1, 4, 5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex
GJ Fredericks, FKW Hoffmann… - Proceedings of the …, 2014 - National Acad Sciences
Calcium (Ca2+) is a secondary messenger in cells and Ca2+ flux initiated from endoplasmic
reticulum (ER) stores via inositol 1, 4, 5-triphosphate (IP3) binding to the IP3 receptor (IP3R) …
reticulum (ER) stores via inositol 1, 4, 5-triphosphate (IP3) binding to the IP3 receptor (IP3R) …
A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1)
Store-operated Ca 2+ entry, essential for the adaptive immunity, is initiated by the
endoplasmic reticulum (ER) Ca 2+ sensor STIM1. Ca 2+ entry occurs through the plasma …
endoplasmic reticulum (ER) Ca 2+ sensor STIM1. Ca 2+ entry occurs through the plasma …