Background Psychotherapy is the treatment of choice for patients with anorexia nervosa,
although evidence of efficacy is weak. The Anorexia Nervosa Treatment of OutPatients …

Background Adjustment for prognostic covariates can lead to increased power in the
analysis of randomized trials. However, adjusted analyses are not often performed in …

In controlled clinical trials, balanced allocation over covariates is often viewed as an
essential component in ensuring valid treatment comparisons. Minimization, sometimes …

Background In-patient treatment (IP) is the treatment setting of choice for moderately-to-
severely ill adolescents with anorexia nervosa, but it is costly, and the risks of relapse and …

Background Analysis of variance (ANOVA), change-score analysis (CSA) and analysis of
covariance (ANCOVA) respond differently to baseline imbalance in randomized controlled …

Stratified permuted block randomization has been the dominant covariate‐adaptive
randomization procedure in clinical trials for several decades. Its high probability of …

In this paper, the authors describe developments in adaptive design methodology and
discuss implementation strategies and operational challenges in early-phase adaptive …

Background: In clinical trials patients are commonly recruited sequentially over time
incurring the risk of chronological bias due to (unobserved) time trends. To minimize the risk …

Biased-coin designs are used in clinical trials to allocate treatments with some randomness
while maintaining approximately equal allocation. More recent rules are compared with …

A permutation test assigns ap‐value by conditioning on the data and treating the different
possible treatment assignments as random. The fact that the conditional type I error rate …