DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos
DM Messerschmidt, BB Knowles… - Genes & …, 2014 - genesdev.cshlp.org
Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …
embryonic development, cells are directed toward their future lineages, and DNA …
The role of DNA methylation in stress-related psychiatric disorders
Epigenetic modifications in response to traumatic experience and stress are emerging as
important factors in the long-term biological trajectories leading to stress-related psychiatric …
important factors in the long-term biological trajectories leading to stress-related psychiatric …
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation
Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2
play an essential role in gene regulation, cellular differentiation, and development. However …
play an essential role in gene regulation, cellular differentiation, and development. However …
DNA methylation and body-mass index: a genome-wide analysis
KJ Dick, CP Nelson, L Tsaprouni, JK Sandling, D Aïssi… - The Lancet, 2014 - thelancet.com
Background Obesity is a major health problem that is determined by interactions between
lifestyle and environmental and genetic factors. Although associations between several …
lifestyle and environmental and genetic factors. Although associations between several …
The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes
Integrating the genotype with epigenetic marks holds the promise of better understanding
the biology that underlies the complex interactions of inherited and environmental …
the biology that underlies the complex interactions of inherited and environmental …
DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns
Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels
DNA methylation is an important epigenetic regulator of gene expression. Recent studies
have revealed widespread associations between genetic variation and methylation levels …
have revealed widespread associations between genetic variation and methylation levels …
Effects of cytosine methylation on transcription factor binding sites
Background DNA methylation in promoters is closely linked to downstream gene repression.
However, whether DNA methylation is a cause or a consequence of gene repression …
However, whether DNA methylation is a cause or a consequence of gene repression …
Ontogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse
G Auclair, S Guibert, A Bender, M Weber - Genome biology, 2014 - Springer
Background In the mouse, the patterns of DNA methylation are established during early
embryonic development in the epiblast. We quantified the targets and kinetics of DNA …
embryonic development in the epiblast. We quantified the targets and kinetics of DNA …
Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells
Z Shipony, Z Mukamel, NM Cohen, G Landan… - Nature, 2014 - nature.com
Stable maintenance of gene regulatory programs is essential for normal function in
multicellular organisms. Epigenetic mechanisms, and DNA methylation in particular, are …
multicellular organisms. Epigenetic mechanisms, and DNA methylation in particular, are …