The innate immune system utilizes pattern-recognition receptors (PRRs) to detect the
invasion of pathogens and initiate host antimicrobial responses such as the production of …

Most organisms rely on innate immune receptors to recognize conserved molecular
structures from invading microbes. Two essential innate immune receptors, RIG-I and MDA5 …

CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic
elements. To broadly enable the application of Cas9 in vivo, we established a Cre …

A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

Type I interferon responses are considered the primary means by which viral infections are
controlled in mammals. Despite this view, several pathogens activate antiviral responses in …

Cytoplasmic pattern recognition receptors detect non-self RNAs during virus infections and
initiate antiviral signaling. One receptor, MDA5, possesses essential signaling domains, but …

Before they infect red blood cells and cause malaria, Plasmodium parasites undergo an
obligate and clinically silent expansion phase in the liver that is supposedly undetected by …

An abnormal immune response to environmental agents is generally thought to be
responsible for causing chronic respiratory diseases, such as asthma and chronic …

Peste des petits ruminants (PPR) is caused by a Morbillivirus that belongs to the family
Paramyxoviridae. PPR is an acute, highly contagious and fatal disease primarily affecting …

MDA5 is an essential intracellular sensor for several viruses, including picornaviruses, and
elicits antiviral interferon (IFN) responses by recognizing viral dsRNAs. MDA5 has been …