The antileukemic mechanisms of 6-mercaptopurine (6MP) and methotrexate (MTX)
maintenance therapy are poorly understood, but the benefits of several years of …

In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent
childhood hematological malignancy, as well as the leading cause of childhood cancer …

B lymphoblastic leukemia/lymphoma (ALL) are subdivided by the WHO classification into
five subgroups defined by specific translocations and two further subgroups defined by the …

Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
cases, we identified the characteristics of CD66c expression. In addition to the confirmation …

The Children's Oncology Group (COG) AALL0031 study included very high-risk (VHR)
pediatric acute lymphoblastic leukemia (ALL) patients who had an expected 5-year event …

Although most children with ALL can be cured by chemotherapy approaches, allogeneic
hematopoietic cell transplant (HCT) therapy offers a better chance of cure to selected high …

This study was designed to evaluate the prevalence of chromosomal abnormalities and to
identify the specific abnormalities associated with poor prognosis. A total of 2,474 patients …

For children with acute lymphoblastic leukemia, the identification of those at higher risk of
disease recurrence and modifying therapy based on this risk is a critical component to the …

Flow cytometry with its rapidly increasing applications has been using to aid the diagnosis of
hematological disorders for more than two decades. It is also the most commonly used …

The inaugural meeting of 'New Frontiers in Pediatric Allogeneic Stem Cell Transplantation'
organized by the Pediatric Blood and Transplant Consortium (PBMTC) was held at the …