Microdomains in the membrane landscape shape antigen-presenting cell function

M Zuidscherwoude, CM de Winde… - Journal of leukocyte …, 2014 - academic.oup.com
The plasma membrane of immune cells is a highly organized cell structure that is key to the
initiation and regulation of innate and adaptive immune responses. It is well-established that …

HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins

C Haller, B Müller, JV Fritz, M Lamas-Murua… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT HIV-1 Nef and Vpu are thought to optimize virus replication in the infected host,
at least in part via their ability to interfere with vesicular host cell trafficking. Despite the use …

[HTML][HTML] The dual role of tetraspanin CD63 in HIV-1 replication

G Li, MA Endsley, A Somasunderam, SL Gbota… - Virology journal, 2014 - Springer
Background Previously, we showed that the tetraspanin membrane protein CD63 mediates
both early and post-integration stages of the HIV-1 replication cycle. The temporal roles of …

[HTML][HTML] Distinct regions of the large extracellular domain of tetraspanin CD9 are involved in the control of human multinucleated giant cell formation

RS Hulme, A Higginbottom, J Palmer, LJ Partridge… - PLoS …, 2014 - journals.plos.org
Multinucleated giant cells, formed by the fusion of monocytes/macrophages, are features of
chronic granulomatous inflammation associated with infections or the persistent presence of …

[HTML][HTML] Evolution and Structural Analyses of Glossina morsitans (Diptera; Glossinidae) Tetraspanins

EK Murungi, HM Kariithi, V Adunga, M Obonyo… - Insects, 2014 - mdpi.com
Tetraspanins are important conserved integral membrane proteins expressed in many
organisms. Although there is limited knowledge about the full repertoire, evolution and …

HOST PROTEIN INCORPORATION IN HUMAN IMMUNODEFICIENCY VIRUS-1

M Linde - 2014 - jscholarship.library.jhu.edu
Human Immunodeficiency Virus (HIV) incorporates a number of host proteins. These
proteins can provide information on the function of viral proteins, as well as on the general …

The Role of CD63-Large Extracellular Loop on HIV-1 entry and cell to cell transfer

H Burghard - 2014 - edoc.rki.de
Regarding to the World Health Organization's 2011 published list of the top ten causes of
death worldwide, HIV/AIDS is still listed as the 6th most frequent reason for fatality. Previous …